Pirmagrel

Base Information

• Chemical Name: Pirmagrel
• CAS No.: 85691-74-3
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.282
• Hs Code.: 2933990090
• Mol file: 85691-74-3.mol

Synonyms:Pirmagrelum;Pirmgrel;Imidazo(1,5-a)pyridine-5-hexanoic acid;5-(5-carboxypentyl)imidazo[1,5-a]pyridine;Pirmagrelum [Latin];Pirmagrel [USAN:INN];PIRMAGREL;

Chemical Property of Pirmagrel

Chemical Property:

• PSA: 54.60000
• Density: 1.19g/cm³
• LogP: 2.52180

Purity/Quality:

99% ^*data from raw suppliers

PIRMAGREL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Inhibitor (thromboxane synthetase). Pirmagrel is an antithrombotic agent that treats thrombosis and ischaemic heart disorders.

Technology Process of Pirmagrel

There total 9 articles about Pirmagrel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(5-ethoxycarbonylpentyl)-imidazo[1,5-a]pyridine (85691-73-2) → pirmagrel (85691-74-3)

Guidance literature:

With sodium hydroxide; 1.) reflux, 2 h, 2.) ethanol, reflux, 45 min;

DOI:10.1021/jm00380a003

Reference yield:

5-(lithiomethyl)imidazo[1,5-a]pyridine (85703-84-0) + 5-bromopentanoic acid (2067-33-6) + 5-methylimidazo<1,5-a>pyridine (6558-64-1) → pirmagrel (85691-74-3)

Guidance literature:

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

5-(5-carboxypent-4-enyl)-imidazo[1,5-a]pyridine → pirmagrel (85691-74-3)

Guidance literature:

palladium; In methanol;

upstream raw materials:

5-(5-ethoxycarbonylpentyl)-imidazo[1,5-a]pyridine

5-bromo-1,1,1-triethoxypentane

5-methylimidazo<1,5-a>pyridine

ethanol