(R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE

Base Information

• Chemical Name: (R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE
• CAS No.: 485820-12-0
• Molecular Formula: C18H26N2O4
• Molecular Weight: 334.415
• Hs Code.: 29333990
• Mol file: 485820-12-0.mol

Synonyms:benzyl (3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate;

Chemical Property of (R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE

Chemical Property:

• Boiling Point: 471.9±44.0 °C(Predicted)
• PKA: 12.25±0.20(Predicted)
• PSA: 67.87000
• Density: 1.15
• LogP: 3.64110
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-N-Boc-amino-1-cbz-piperidine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE

There total 7 articles about (R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) + benzyl chloroformate (501-53-1,94274-21-2) → (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester (485820-12-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 5 ℃; for 24h;

Reference yield: 46.0%

(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid (160706-62-7) → (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester (485820-12-0)

Guidance literature:

(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid; With triethylamine; tert-butyl alcohol; for 0.5h;

With diphenyl phosphoryl azide; at 100 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (R)-benzyl 3-aminopiperidine-1-carboxylate (1044560-96-4) → (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester (485820-12-0)

Guidance literature:

With sodium carbonate; In methanol; water; at 20 - 25 ℃;

upstream raw materials:

(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

benzyl chloroformate

di-tert-butyl dicarbonate

Downstream raw materials:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

(R)-benzyl 3-(tert-butoxycarbonyl(ethyl)amino)piperidine-1-carboxylate

tert-butyl N-ethyl-N-(3-piperidyl)carbamate

methyl (R)-piperidin-3-ylcarbamic acid tert-butyl ester