1044560-96-4

Basic information

• Product Name: (R)-3-AMINO-1-N-CBZ-PIPERIDINE
• Synonyms: 1-Piperidinecarboxylic acid, 3-amino-, phenylmethyl ester, (3R)-
• CAS NO: 1044560-96-4
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.3
• EINECS: -0
• Mol File: 1044560-96-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 367.235 °C at 760 mmHg
• Flash Point: 175.898 °C
• Appearance: /
• Density: 1.152 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (R)-3-AMINO-1-N-CBZ-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-AMINO-1-N-CBZ-PIPERIDINE(1044560-96-4)
• EPA Substance Registry System: (R)-3-AMINO-1-N-CBZ-PIPERIDINE(1044560-96-4)

Safety Data

• Hazardous Substances Data: 1044560-96-4(Hazardous Substances Data)

Usage

General Description

"(R)-3-Amino-1-N-CBZ-piperidine" is a chemical compound commonly used in scientific research, particularly in the field of chemistry and pharmaceutical studies. Its name refers to its specific structure, wherein a 1-N-CBZ-piperidine molecule (a cyclic compound that is a secondary amine) is combined with an amino group (containing nitrogen and hydrogen atoms). The "(R)" in its name means it is a right-handed isomer, implying it rotates plane polarized light in a clockwise direction. (R)-3-AMINO-1-N-CBZ-PIPERIDINE is often used in the synthesis of more complex molecules, contributing to the development of new drugs and treatments.

InChI:InChI:1S/C13H18N2O2/c14-12-7-4-8-15(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,14H2

Upstream product

• 1050446-94-0 C₁₄H₁₈N₂O₃ 
• 160706-62-7 (R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 
• 78190-11-1 1-benzyloxycarbonylpiperidine-3-carboxylic acid 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 1044560-98-6 Benzyl (3R)-3-(isopropylamino)piperidine-1-carboxylate 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 
• 1353254-40-6 (R)-benzyl 3-(3-bromo-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate 
• 1226804-40-5 (R)-3-[2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethylamino]-piperidine-1-carboxylic acid benzyl ester hydrochloride 

Relevant articles and documents

(R)- 3 - Boc - amino piperidine preparation method

The invention discloses a preparation method of (R)-3-Boc-aminopiperidine and relates to the technical field of preparation of piperidine heterocyclic compounds. The preparation method includes following steps: (1) with N-Cbz-3-piperidinecarboxylic acid as a raw material, performing chiral resolution with R-phenylethylamine to obtain a compound I; (2) performing an acid-amide condensation reaction to the compound I and ammonia gas to obtain a compound II; (3) performing a Hofmann degradation reaction to the compound II to obtain a compound III; (4) performing protection to the compound III with di-tert-butyl dicarbonate to obtain a compound IV; and (5) performing a hydrogenation and Cbz-removal reaction to the compound IV to prepare the (R)-3-Boc-aminopiperidine. The method is mild in reaction conditions, is safe and reliable, is excellent in process stability, is low in energy consumption, is high in yield, is green and environment-protective and is suitable for industrial production.

AMIDE DERIVATIVE

The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, -(CH2)sO-, - (CH2)sN(R4)CO-, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.