1044560-96-4

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-AMINO-1-N-CBZ-PIPERIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs and treatments. Its unique structure allows for the creation of complex molecules with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, (R)-3-AMINO-1-N-CBZ-PIPERIDINE serves as a valuable compound for studying the properties and reactions of cyclic secondary amines and amino groups. Its right-handed isomer characteristic enables researchers to explore the effects of chirality on molecular interactions and reactivity.
Used in Drug Development:
(R)-3-AMINO-1-N-CBZ-PIPERIDINE is employed as a building block in the design and synthesis of innovative drug candidates. Its incorporation into molecular structures can lead to the discovery of novel therapeutic agents with improved efficacy, selectivity, and safety profiles.
Used in Organic Synthesis:
In organic synthesis, (R)-3-AMINO-1-N-CBZ-PIPERIDINE is utilized as a versatile reagent for the preparation of a wide range of organic compounds. Its unique structural features facilitate various chemical transformations, enabling the synthesis of complex organic molecules with potential applications in various industries.

InChI:InChI:1S/C13H18N2O2/c14-12-7-4-8-15(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,14H2

Upstream product

• 1050446-94-0 C₁₄H₁₈N₂O₃ 
• 160706-62-7 (R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 
• 78190-11-1 1-benzyloxycarbonylpiperidine-3-carboxylic acid 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 1044560-98-6 Benzyl (3R)-3-(isopropylamino)piperidine-1-carboxylate 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 
• 1353254-40-6 (R)-benzyl 3-(3-bromo-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate 
• 1226804-40-5 (R)-3-[2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethylamino]-piperidine-1-carboxylic acid benzyl ester hydrochloride 

Relevant academic research and scientific papers

(R)- 3 - Boc - amino piperidine preparation method

The invention discloses a preparation method of (R)-3-Boc-aminopiperidine and relates to the technical field of preparation of piperidine heterocyclic compounds. The preparation method includes following steps: (1) with N-Cbz-3-piperidinecarboxylic acid as a raw material, performing chiral resolution with R-phenylethylamine to obtain a compound I; (2) performing an acid-amide condensation reaction to the compound I and ammonia gas to obtain a compound II; (3) performing a Hofmann degradation reaction to the compound II to obtain a compound III; (4) performing protection to the compound III with di-tert-butyl dicarbonate to obtain a compound IV; and (5) performing a hydrogenation and Cbz-removal reaction to the compound IV to prepare the (R)-3-Boc-aminopiperidine. The method is mild in reaction conditions, is safe and reliable, is excellent in process stability, is low in energy consumption, is high in yield, is green and environment-protective and is suitable for industrial production.

AKT AND P70 S6 KINASE INHIBITORS

The present invention provides AKT and p70 S6 kinase inhibitors of the formula: The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and methods of using compounds of Formula I.

AMIDE DERIVATIVE

The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, -(CH2)sO-, - (CH2)sN(R4)CO-, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.