6-fluoro-5-nitro-1H-indazole

Base Information

• Chemical Name: 6-fluoro-5-nitro-1H-indazole
• CAS No.: 633327-51-2
• Molecular Formula: C₇H₄FN₃O₂
• Molecular Weight: 181.126
• Hs Code.: 2933998090
• Mol file: 633327-51-2.mol

Synonyms:6-Fluoro-5-nitroindazole;

Chemical Property of 6-fluoro-5-nitro-1H-indazole

Chemical Property:

• Vapor Pressure: 2.79E-06mmHg at 25°C
• Refractive Index: 1.704
• Boiling Point: 401.2 °C at 760 mmHg
• PKA: 10.92±0.40(Predicted)
• Flash Point: 196.4 °C
• PSA: 74.50000
• Density: 1.629 g/cm³
• LogP: 2.13340

Purity/Quality:

97% ^*data from raw suppliers

6-fluoro-5-nitro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-fluoro-5-nitro-1H-indazole

There total 7 articles about 6-fluoro-5-nitro-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

6-fluoro-1H-indazole (348-25-4) → 5-nitro-6-fluoro-1H-indazole (633327-51-2)

Guidance literature:

With sulfuric acid; potassium nitrate; at 0 - 20 ℃; for 0.166667h;

Reference yield: 21.0%

5-fluoro-2-methyl-4-nitrophenylamine (633327-50-1) → 5-nitro-6-fluoro-1H-indazole (633327-51-2)

Guidance literature:

With acetic acid; sodium nitrite; In water; for 2h; Cooling with ice;

Reference yield:

3-fluoro-6-methylaniline (367-29-3) → 5-nitro-6-fluoro-1H-indazole (633327-51-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium acetate / CHCl₃ / 20 - 40 °C

1.2: isoamyl nitrite / CHCl₃ / 18 h / 60 °C

2.1: 4.80 g / HCl / methanol / 5 h / 80 °C

3.1: 3.00 g / sodium nitrate; H₂SO₄ / H₂O / 1 h / 20 °C

With hydrogenchloride; sodium nitrate; sulfuric acid; potassium acetate; In methanol; chloroform; water;

DOI:10.1016/j.bmc.2004.02.025

upstream raw materials:

6-fluoro-1H-indazole

3-fluoro-6-methylaniline

6-fluoro-1-acetylindazole

5-fluoro-2-methyl-4-nitrophenylamine

Downstream raw materials:

5-amino-6-fluoro-1H-indazole

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