2-AMINO-4-FLUORO-5-NITROTOLUENE

Base Information

• Chemical Name: 2-AMINO-4-FLUORO-5-NITROTOLUENE
• CAS No.: 633327-50-1
• Molecular Formula: C7H7FN2O2
• Molecular Weight: 170.143
• Hs Code.: 2921430090
• Mol file: 633327-50-1.mol

Synonyms:2-Amino-4-fluoro-5-nitrotoluene;5-fluoro-2-methyl-4-nitro-phenylamine;

Chemical Property of 2-AMINO-4-FLUORO-5-NITROTOLUENE

Chemical Property:

• Vapor Pressure: 6.6E-05mmHg at 25°C
• Boiling Point: 344.4oC at 760 mmHg
• PKA: -0.09±0.14(Predicted)
• Flash Point: 162.1oC
• PSA: 71.84000
• Density: 1.371g/cm3
• LogP: 2.72890

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-methyl-4-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-2-methyl-4-nitroaniline

Technology Process of 2-AMINO-4-FLUORO-5-NITROTOLUENE

There total 3 articles about 2-AMINO-4-FLUORO-5-NITROTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide (633327-49-8) → 5-fluoro-2-methyl-4-nitrophenylamine (633327-50-1)

Guidance literature:

With hydrogenchloride; In water; for 1.5h; Reflux;

Reference yield:

5’-fluoro-2’-methylacetanilide (366-49-4) → 5-fluoro-2-methyl-4-nitrophenylamine (633327-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 1 h / 0 °C

2: hydrogenchloride / water / 1.5 h / Reflux

With hydrogenchloride; sulfuric acid; nitric acid; In water;

Reference yield:

3-fluoro-6-methylaniline (367-29-3) → 5-fluoro-2-methyl-4-nitrophenylamine (633327-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

2: nitric acid; sulfuric acid / 1 h / 0 °C

3: hydrogenchloride / water / 1.5 h / Reflux

With hydrogenchloride; sulfuric acid; nitric acid; triethylamine; In dichloromethane; water;

upstream raw materials:

N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide

5’-fluoro-2’-methylacetanilide

3-fluoro-6-methylaniline

Downstream raw materials:

5-nitro-6-fluoro-1H-indazole

N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide

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