7-Bromo-2-chloroquinazoline

Base Information

• Chemical Name: 7-Bromo-2-chloroquinazoline
• CAS No.: 953039-66-2
• Molecular Formula: C8H4BrClN2
• Molecular Weight: 243.49
• Hs Code.: 2933990090
• Mol file: 953039-66-2.mol

Synonyms:7-bromo-2-chloroquinazoline;7-BroMo-2-chloroquinazoli...;Quinazoline, 7-broMo-2-chloro-

Chemical Property of 7-Bromo-2-chloroquinazoline

Chemical Property:

• Vapor Pressure: 0.0596mmHg at 25°C
• Refractive Index: 1.691
• Boiling Point: 240.2 °C at 760 mmHg
• PKA: -0.51±0.30(Predicted)
• Flash Point: 99.1 °C
• PSA: 25.78000
• Density: 1.763 g/cm³
• LogP: 3.04570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromo-2-chloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromo-2-chloroquinazoline

There total 5 articles about 7-Bromo-2-chloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

7-bromo-quinazolin-2-ol (953039-65-1) → 7-bromo-2-chloroquinazoline (953039-66-2)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 1h;

Reference yield:

4-bromo-2-nitrobenzaldehyde (5551-12-2) → 7-bromo-2-chloroquinazoline (953039-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; iron; hydrogenchloride / ethanol / 70 °C

2: 180 °C

3: trichlorophosphate / 110 °C

With hydrogenchloride; iron; acetic acid; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2013.10.008

Reference yield:

4-bromo-2-nitrobenzoic acid (99277-71-1) → 7-bromo-2-chloroquinazoline (953039-66-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: borane / tetrahydrofuran / 48 h / 0 - 20 °C

1.2: 0 °C

2.1: manganese(IV) oxide / dichloromethane / 12 h / 20 °C

3.1: iron; acetic acid / ethanol / 1.5 h / 20 °C

4.1: 1 h / 180 °C

5.1: trichlorophosphate / 1 h / 110 °C

With manganese(IV) oxide; borane; iron; acetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

7-bromo-quinazolin-2-ol

4-bromo-2-nitrobenzaldehyde

2-amino-4-bromobenzaldehyde

4-bromo-2-nitrobenzoic acid

Downstream raw materials:

C₂₅H₁₉N₉

C₂₂H₁₆BrN₇

C₂₆H₂₃N₇O

C₂₆H₂₄N₈O

Refernces

• 1、 Bursavich, Matthew G.,Dastrup, David,Shenderovich, Mark,Yager, Kraig M.,Cimbora, Daniel M.,Williams, Brandi,Kumar, D. Vijay. "Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads". . p. 6829 - 6833. Retrieved 2014/01/06.