2-CHLORO-7-METHOXYQUINAZOLINE

Base Information

• Chemical Name: 2-CHLORO-7-METHOXYQUINAZOLINE
• CAS No.: 953039-15-1
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Hs Code.: 2933990090
• Mol file: 953039-15-1.mol

Synonyms:2-CHLORO-7-METHOXYQUINAZOLINE

Chemical Property of 2-CHLORO-7-METHOXYQUINAZOLINE

Chemical Property:

• PSA: 35.01000
• LogP: 2.29180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-7-methoxyquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-7-METHOXYQUINAZOLINE

There total 5 articles about 2-CHLORO-7-METHOXYQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-bromo-2-chloroquinazoline (953039-66-2) + sodium methylate (124-41-4) → 2-chloro-7-methoxyquinazoline (953039-15-1)

Guidance literature:

With copper(I) bromide; In methanol; N,N-dimethyl-formamide; Inert atmosphere; Reflux;

Reference yield:

2-hydroxy-7-methoxyquinazoline (91099-24-0) → 2-chloro-7-methoxyquinazoline (953039-15-1)

Guidance literature:

With trichlorophosphate; for 6h; Heating / reflux;

Reference yield:

4-Methyl-3-nitroanisole (17484-36-5) → 2-chloro-7-methoxyquinazoline (953039-15-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4.5 h / Heating / reflux

1.2: 20 °C

2.1: hydrogenchloride; iron; acetic acid / ethanol; water / 1 h / 60 - 65 °C

3.1: 1 h / 160 - 180 °C

4.1: trichlorophosphate / 6 h / Heating / reflux

With hydrogenchloride; N-Bromosuccinimide; iron; acetic acid; trichlorophosphate; dibenzoyl peroxide; In tetrachloromethane; ethanol; water;

upstream raw materials:

2-hydroxy-7-methoxyquinazoline

7-bromo-2-chloroquinazoline

sodium methylate

4-Methyl-3-nitroanisole

Downstream raw materials:

2-(4-(morpholine-4-sulfonyl)phenylamino)-quinazolin-7-yl trifluoromethanesulfonate

2-(4-morpholin-4-ylsulfonyl-phenylamino)-quinazolin-7-ol