6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE

Base Information

• Chemical Name: 6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE
• CAS No.: 916420-30-9
• Molecular Formula: C₆H₃BrClN₃
• Molecular Weight: 232.467
• Mol file: 916420-30-9.mol

Synonyms:Pyrrolo[2,1-f][1,2,4]triazine, 6-bromo-4-chloro-;6-Bromo-4-chloropyrrolo[1,2-f][1,2,4]triazine;TC-068164;

Chemical Property of 6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE

Chemical Property:

• Refractive Index: 1.767
• PKA: -4.36±0.30(Predicted)
• PSA: 30.19000
• Density: 2.03 g/cm³
• LogP: 2.14520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

6-Bromo-4-chloropyrrolo[2,1-f][1,2,4]triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromo-4-chloropyrrolo[2,1-f][1,2,4]triazine is used in preparation of the condensed pyridazine or pyrimidine as btk inhibitors.

Technology Process of 6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE

There total 3 articles about 6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

6-bromo-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one → 6-bromo-4-chloro-pyrrolo[2,1-f][1,2,4]triazine (916420-30-9)

Guidance literature:

With trichlorophosphate; at 130 ℃; for 3h;

Reference yield:

methyl 4-bromo-1H-pyrrole-2-carboxylate (934-05-4) → 6-bromo-4-chloro-pyrrolo[2,1-f][1,2,4]triazine (916420-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 1 h

2.1: formamide / 5 h / 180 °C

3.1: trichlorophosphate / 3 h / 130 °C

With sodium hydride; formamide; trichlorophosphate; In N,N-dimethyl-formamide;

Reference yield:

1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester (1208361-39-0) → 6-bromo-4-chloro-pyrrolo[2,1-f][1,2,4]triazine (916420-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: formamide / 5 h / 180 °C

2: trichlorophosphate / 3 h / 130 °C

With formamide; trichlorophosphate;

upstream raw materials:

1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester

methyl 4-bromo-1H-pyrrole-2-carboxylate

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