4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

Base Information

• Chemical Name: 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid
• CAS No.: 1456885-53-2
• Molecular Formula: C₂₈H₃₅N₃O₅
• Molecular Weight: 493.603
• Mol file: 1456885-53-2.mol

Synonyms:

Chemical Property of 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

There total 4 articles about 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-piperidin-4-yl-pyrrolidine-1-carboxylic acid tert-butyl ester (929974-12-9,1449131-15-0,1451390-44-5) + 2-(phenylamino)terephthalic acid (566155-75-7) → 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid (1456885-53-2)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1021/jm400919p

Reference yield:

2-bromo-1,4-benzenedicarboxylic acid (586-35-6) → 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid (1456885-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; copper(l) iodide; copper / water / Reflux

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

With copper(l) iodide; copper; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm400919p

Reference yield:

di-tert-butyl 2-bromoterephthalate (1456885-46-3) → 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid (1456885-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl acetamide / Reflux

2: potassium carbonate; copper(l) iodide; copper / water / Reflux

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

With copper(l) iodide; copper; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

DOI:10.1021/jm400919p

upstream raw materials:

2-piperidin-4-yl-pyrrolidine-1-carboxylic acid tert-butyl ester

2-(phenylamino)terephthalic acid

2-bromo-1,4-benzenedicarboxylic acid

di-tert-butyl 2-bromoterephthalate