1456885-46-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 586-35-6 2-bromo-1,4-benzenedicarboxylic acid 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 

Downstream Products

• 586-35-6 2-bromo-1,4-benzenedicarboxylic acid 
• 25539-20-2 2-(phenoxy)terephthalic acid 
• 1456885-59-8 4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid 
• 1456885-57-6 4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid 
• 1456885-53-2 4-(4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carbonyl)-2-(phenylamino)benzoic acid trifluoroacetic acid 
• 566155-75-7 2-(phenylamino)terephthalic acid 

Relevant academic research and scientific papers

Rhodamines with a Chloronicotinic Acid Fragment for Live Cell Superresolution STED Microscopy**

Formylation of 2,6-dichloro-5-R-nicotinic acids at C-4 followed by condensation with 3-hydroxy-N,N-dimethylaniline gave analogs of the popular TAMRA fluorescent dye with a 2,6-dichloro-5-R-nicotinic acid residues (R=H, F). The following reaction with thioglycolic acid is selective, involves only one chlorine atom at the carbon between pyridine nitrogen and the carboxylic acid group and affords new rhodamine dyes absorbing at 564/ 573 nm and emitting at 584/ 597 nm (R=H/ F, in aq. PBS). Conjugates of the dyes with “small molecules” provided specific labeling (covalent and non-covalent) of organelles as well as of components of the cytoskeleton in living cells and were combined with fluorescent probes prepared from 610CP and SiR dyes and applied in two-color STED microscopy with a 775 nm STED laser.

Fluorescent Rhodamines and Fluorogenic Carbopyronines for Super-Resolution STED Microscopy in Living Cells

A range of bright and photostable rhodamines and carbopyronines with absorption maxima in the range of λ=500-630 nm were prepared, and enabled the specific labeling of cytoskeletal filaments using HaloTag technology followed by staining with 1 μm solution

AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS

The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.