5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine

Base Information

• Chemical Name: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine
• CAS No.: 944401-57-4
• Molecular Formula: C12H16BF3N2O2
• Molecular Weight: 288.077
• Hs Code.: 2934999090
• Mol file: 944401-57-4.mol

Synonyms:5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine

Chemical Property of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine

Chemical Property:

• Boiling Point: 375.0±42.0 °C(Predicted)
• PKA: 4.83±0.37(Predicted)
• PSA: 57.37000
• Density: 1.23
• LogP: 2.56300
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-(trifluoromethyl)pyridine-5-boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4-(trifluoromethyl)pyridine-5-boronic acid pinacol ester is used as pharmaceutical intermediate.

Technology Process of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine

There total 1 articles about 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-amino-5-bromo-4-(trifluoromethyl)pyridine (944401-56-3) + bis(pinacol)diborane (73183-34-3) → 4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine (944401-57-4) + 2-amino-4-(trifluoromethyl)pyridine (106447-97-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 115 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ml200156t

Reference yield: 47.4%

4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine (944401-57-4) + C21H26ClN5O2 → C27H30F3N7O2

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; for 6h; Reflux;

Reference yield: 35.0%

4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine (944401-57-4) + 1-(6-chloro-2-morpholinopyrimidin-4-yl)-3-phenylimidazolidin-2-one (944402-02-2) → 1-(6-(6-amino-4-(trifluoromethyl)pyridin-3-yl)-2-morpholinopyrimidin-4-yl)-3-phenylimidazolidin-2-one

Guidance literature:

With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 95 ℃; for 5h;

upstream raw materials:

2-amino-5-bromo-4-(trifluoromethyl)pyridine

bis(pinacol)diborane

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