3-[9-(((3-(N-succiniMidyloxycarboxypropyl)[4-Methxylphenyl]sulfonyl)aMine)carboxyl]-10-acridiniuMyl)-1-propanesulfonate inner salt (NSP-SA-NHS)

Base Information

• Chemical Name: 3-[9-(((3-(N-succiniMidyloxycarboxypropyl)[4-Methxylphenyl]sulfonyl)aMine)carboxyl]-10-acridiniuMyl)-1-propanesulfonate inner salt (NSP-SA-NHS)
• CAS No.: 199293-83-9
• Molecular Formula: C32H31N3O10S2
• Molecular Weight: 681.744
• Mol file: 199293-83-9.mol

Synonyms:(NSP-SA-NHS);

Chemical Property of 3-[9-(((3-(N-succiniMidyloxycarboxypropyl)[4-Methxylphenyl]sulfonyl)aMine)carboxyl]-10-acridiniuMyl)-1-propanesulfonate inner salt (NSP-SA-NHS)

Chemical Property:

• PSA: 195.97000
• LogP: 4.84220

Purity/Quality:

98%, ^*data from raw suppliers

NSP-SA-NHS 99.14% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: NSP-SA-NHS can be used for the labeling of proteins, antigens, antibodies, nucleic acids (DNA, RNA), etc.

Technology Process of 3-[9-(((3-(N-succiniMidyloxycarboxypropyl)[4-Methxylphenyl]sulfonyl)aMine)carboxyl]-10-acridiniuMyl)-1-propanesulfonate inner salt (NSP-SA-NHS)

There total 7 articles about 3-[9-(((3-(N-succiniMidyloxycarboxypropyl)[4-Methxylphenyl]sulfonyl)aMine)carboxyl]-10-acridiniuMyl)-1-propanesulfonate inner salt (NSP-SA-NHS) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-trifluoroacetoxy succinimide (5672-89-9) + 9-[[(3-carboxypropyl)[(4-methylphenyl)sulfonyl]amino]carbonyl]-10-(3-sulfopropyl)-acridinium inner salt (211106-69-3) → 3-[9-({{4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl}[(4-methylphenyl)sulfonyl]amino}carbonyl)-10-acridiniumyl]-1-propanesulfonate (199293-83-9)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; for 24h;

DOI:10.1016/S0039-128X(00)00091-X

Reference yield: 92.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 9-[[(3-carboxypropyl)[(4-methylphenyl)sulfonyl]amino]carbonyl]-10-(3-sulfopropyl)-acridinium inner salt (211106-69-3) → 3-[9-({{4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl}[(4-methylphenyl)sulfonyl]amino}carbonyl)-10-acridiniumyl]-1-propanesulfonate (199293-83-9)

Guidance literature:

With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 ℃; for 8h; Solvent; Inert atmosphere;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 3-[9-({{4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl}[(4-methylphenyl)sulfonyl]amino}carbonyl)-10-acridiniumyl]-1-propanesulfonate (199293-83-9)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: sodium hydride / dichloromethane / 7 h / 20 °C / Inert atmosphere

3: 1-methyl-pyrrolidin-2-one / 26 h / 125 °C / Inert atmosphere

4: hydrogenchloride / 16 h / 80 °C / Inert atmosphere

5: 1,1'-carbonyldiimidazole / acetonitrile / 8 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetonitrile;

upstream raw materials:

N-trifluoroacetoxy succinimide

9-[[(3-carboxypropyl)[(4-methylphenyl)sulfonyl]amino]carbonyl]-10-(3-sulfopropyl)-acridinium inner salt

p-toluenesulfonyl chloride

1-hydroxy-pyrrolidine-2,5-dione

Downstream raw materials:

C₆₄H₆₉N₇O₁₇S₄

3-[9-({(3-carboxypropyl)[(4-methylphenyl) sulfonyl] amino}carbonyl)-10-acridiniumyl]-1-propanesulfonate-valproate

NSP-AS-ED-carbamazepine conjugate

NSP-AS-HD-theophylline conjugate