6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine

Base Information

• Chemical Name: 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine
• CAS No.: 1323401-68-8
• Molecular Formula: C₂₈H₂₀ClN₅O₃S₂
• Molecular Weight: 574.083
• Mol file: 1323401-68-8.mol

Synonyms:

Chemical Property of 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine

There total 4 articles about 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-Aminomethylpyridine (3731-52-0) + 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-methylthio-1,4,2-benzodithiazine (1323401-53-1) → 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine (1323401-68-8)

Guidance literature:

In methanol; at 20 ℃; Reflux;

DOI:10.1002/ardp.201000183

Reference yield:

N-[2-(4-methylphenylcarbamoyl)phenyl]-6-chloro-1,1-dioxo-3-methylthio-1,4,2-benzodithiazin-7-carboxamide (1323401-51-9) → 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine (1323401-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 30 h / Reflux

2: methanol / 20 °C / Reflux

With thionyl chloride; In methanol;

DOI:10.1002/ardp.201000183

Reference yield:

2-amino-N-(4-methylphenyl)benzamide (32212-38-7) → 6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-[(3-pyridylmethyl)amino]-1,4,2-benzodithiazine (1323401-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / toluene / 48 h / Reflux

2: thionyl chloride / 30 h / Reflux

3: methanol / 20 °C / Reflux

With pyridine; thionyl chloride; In methanol; toluene;

DOI:10.1002/ardp.201000183

upstream raw materials:

3-Aminomethylpyridine

6-chloro-1,1-dioxo-7-{4-[(4-methylphenyl)imino]-4H-3,1-benzoxazin-2-yl}-3-methylthio-1,4,2-benzodithiazine

N-[2-(4-methylphenylcarbamoyl)phenyl]-6-chloro-1,1-dioxo-3-methylthio-1,4,2-benzodithiazin-7-carboxamide

chlorek kwasu 6-chloro-3-metylotio-1,1-diokso-1,4,2-benzoditiazyno-7-karboksylowego