2-chloro-6-fluorobromobenzene

Base Information

• Chemical Name: 2-chloro-6-fluorobromobenzene
• CAS No.: 309721-44-6
• Molecular Formula: C6H3BrClF
• Molecular Weight: 209.445
• Hs Code.: 2903999090
• Mol file: 309721-44-6.mol

Synonyms:2-bromo-3-fluoro-chlorobenzene;2-chloro-6-fluorobromobenzene;

Chemical Property of 2-chloro-6-fluorobromobenzene

Chemical Property:

• Vapor Pressure: 0.525mmHg at 25°C
• Boiling Point: 197.73oC at 760 mmHg
• Flash Point: 73.385oC
• PSA: 0.00000
• Density: 1.72g/cm3
• LogP: 3.24160
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-1-chloro-3-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-fluorobromobenzene

There total 1 articles about 2-chloro-6-fluorobromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-chlorofluorobenzene (625-98-9) → 2-bromo-3-fluoro-chlorobenzene (309721-44-6)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 3h; Inert atmosphere;

With bromine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201703591

Reference yield: 86.0%

9,9'-spirobi[9H-fluorene]-4-ol + 2-bromo-3-fluoro-chlorobenzene (309721-44-6) → C31H18BrClO

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 3h;

Reference yield: 79.0%

(1H-benzoimidazol-2-yl)phenylamine (21578-58-5) + 2-bromo-3-fluoro-chlorobenzene (309721-44-6) → C19H12ClN3

Guidance literature:

With potassium phosphate; In N,N-dimethyl acetamide; at 160 ℃; for 15h; Inert atmosphere;

upstream raw materials:

3-chlorofluorobenzene

Downstream raw materials:

N-(2-chloro-6-fluoro-phenyl)-4-methylaniline

lumiracoxib

1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one

2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide