2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

Base Information

Chemical Name:2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide
CAS No.:332903-78-3
Molecular Formula:C₁₅H₁₂Cl₂FNO
Molecular Weight:312.171
Hs Code.:
DSSTox Substance ID:DTXSID701335334
Nikkaji Number:J2.123.098G
Mol file:332903-78-3.mol

Synonyms:SCHEMBL2072692;SVCPNJWCSAOMAH-UHFFFAOYSA-N;DTXSID701335334;332903-78-3;NS00077803;2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide;N-(2'-chloro-6'-fluorophenyl)-N-chloroacetyl-4-methylaniline;N-(2'-chloro-6'-fluorophenyl)-N-chloroacetyl4-methylaniline;2-chloro-N-(2'-chloro-6'-fluorophenyl)-N-(4-methylphenyl)acetamide

Suppliers and Price of 2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:311.0279976
Heavy Atom Count:20
Complexity:334

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)N(C2=C(C=CC=C2Cl)F)C(=O)CCl

Technology Process of 2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

There total 9 articles about 2-Chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 79-04-9
chloroacetyl chloride

: 332903-74-9
N-(2-chloro-6-fluoro-phenyl)-4-methylaniline

: 332903-78-3
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

Guidance literature:: In toluene; at 80 - 90 ℃;
DOI:10.1016/j.tet.2004.09.064

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 332903-78-3
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C

2: 82 percent / toluene / 80 - 90 °C

With (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; 1: Buchwald-Hartwig coupling;
DOI:10.1016/j.tet.2004.09.064

Reference yield:

: 309721-44-6
2-bromo-3-fluoro-chlorobenzene

: 332903-78-3
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C

2: 82 percent / toluene / 80 - 90 °C

With (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; 1: Buchwald-Hartwig coupling;
DOI:10.1016/j.tet.2004.09.064