1-(2-Methoxy-5-trifluoromethylphenyl)ethanone

Base Information

Chemical Name:1-(2-Methoxy-5-trifluoromethylphenyl)ethanone
CAS No.:503464-99-1
Molecular Formula:C10H9F3O2
Molecular Weight:218.175
Hs Code.:2914790090
DSSTox Substance ID:DTXSID00433137
Wikidata:Q82247262
Mol file:503464-99-1.mol

Synonyms:503464-99-1;1-(2-Methoxy-5-trifluoromethylphenyl)ethanone;1-(2-methoxy-5-(trifluoromethyl)phenyl)ethanone;1-[2-methoxy-5-(trifluoromethyl)phenyl]ethanone;2'-METHOXY-5'-(TRIFLUOROMETHYL)ACETOPHENONE;1-(2-Methoxy-5-trifluoromethyl-phenyl)-ethanone;1-[2-methoxy-5-(trifluoromethyl)phenyl]ethan-1-one;Ethanone, 1-[2-methoxy-5-(trifluoromethyl)phenyl]-;SCHEMBL320173;DTXSID00433137;MFCD09832300;AKOS015956628;JS-4591;SB37378;2'-methoxy-5'-trifluoromethyl-acetophenone;2'-Methoxy-5-(trifluoromethyl)acetophenone;CS-0188339;FT-0647146;F13148;EN300-2007171

Suppliers and Price of 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2'-Methoxy-5'-(trifluoromethyl)acetophenone
10 g
$ 360.00

SynQuest Laboratories
2'-Methoxy-5'-(trifluoromethyl)acetophenone
5 g
$ 199.00

Rieke Metals
1-(2-Methoxy-5-trifluoromethyl-phenyl)-ethanone
1g
$ 260.00

Rieke Metals
1-(2-Methoxy-5-trifluoromethyl-phenyl)-ethanone
5g
$ 661.00

Matrix Scientific
2'-Methoxy-5'-(trifluoromethyl)acetophenone
10g
$ 534.00

Matrix Scientific
2'-Methoxy-5'-(trifluoromethyl)acetophenone
5g
$ 294.00

J&W Pharmlab
1-(2-Methoxy-5-trifluoromethyl-phenyl)-ethanone 97%
5g
$ 998.00

Crysdot
1-(2-Methoxy-5-trifluoromethylphenyl)ethanone 97%
5g
$ 710.00

Crysdot
1-(2-Methoxy-5-trifluoromethylphenyl)ethanone 97%
1g
$ 207.00

Apolloscientific
2'-Methoxy-5'-(trifluoromethyl)acetophenone 98%
5g
$ 180.00

Total 17 raw suppliers

Chemical Property of 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone

Chemical Property:

Melting Point:45-47℃
Boiling Point:230.138oC at 760 mmHg
Flash Point:90.457oC
PSA：26.30000
Density:1.222g/cm3
LogP:2.91660
Solubility.:Slightly soluble.
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:218.05546401
Heavy Atom Count:15
Complexity:237

Purity/Quality:

99%, ^*data from raw suppliers

2'-Methoxy-5'-(trifluoromethyl)acetophenone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C(C=CC(=C1)C(F)(F)F)OC
Uses In synthesis and evaluation of disubstituted N1- and N3-Imidazolidin-2-ones Acting as Potential Immunosuppressive Agents

Technology Process of 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone

There total 3 articles about 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 402-52-8
methyl 4-(trifluoromethyl)phenyl ether

: 108-24-7
acetic anhydride

: 503464-99-1
1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one

Guidance literature:: trifluorormethanesulfonic acid; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 402-52-8
methyl 4-(trifluoromethyl)phenyl ether

: 503464-99-1
1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one

Guidance literature:: With trifluorormethanesulfonic acid; acetic anhydride; In water;

Reference yield:

: 402-45-9
4-hydroxybenzotrifluoride

: 503464-99-1
1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 0 °C / Reflux

2: trifluorormethanesulfonic acid / 0 - 20 °C

With trifluorormethanesulfonic acid; potassium carbonate; In acetone;
DOI:10.1016/j.bmcl.2011.08.093