5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

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Chemical Name:5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide
CAS No.:1354818-97-5
Molecular Formula:C₂₂H₁₇ClF₄N₆O₃S₂
Molecular Weight:588.994
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

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Chemical Property of 5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

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Technology Process of 5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

There total 7 articles about 5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1354818-96-4
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-5-chloro-2-fluoro-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-5-yl benzenesulfonamide

: 1354818-97-5
5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

Guidance literature:: formaldehyd; 4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-5-chloro-2-fluoro-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-5-yl benzenesulfonamide; With acetic acid; In methanol; dichloromethane; at 0 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; for 3h;

Reference yield:

: 67589-15-5
1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one

: 1354818-97-5
5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.5 h / 110 °C

2.1: acetic acid / ethanol / 0 - 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

5.1: acetic acid / dichloromethane; methanol / 0.25 h / 0 °C

5.2: 3 h

With potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 503464-99-1
1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one

: 1354818-97-5
5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide; tetra-(n-butyl)ammonium iodide / dichloromethane / 0 - 20 °C

1.2: Cooling with ice

2.1: 0.5 h / 110 °C

3.1: acetic acid / ethanol / 0 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

6.1: acetic acid / dichloromethane; methanol / 0.25 h / 0 °C

6.2: 3 h

With boron tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane; dimethyl sulfoxide;