4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

Base Information

Chemical Name:4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid
CAS No.:1289570-77-9
Molecular Formula:C₃₁H₂₈Cl₂F₃N₃O₃
Molecular Weight:618.483
Hs Code.:

4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

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Chemical Property of 4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

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Technology Process of 4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

There total 8 articles about 4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1289570-77-9
4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

: 1289570-78-0
4-({[(2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl]amino}methyl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; tetrahydrofuran / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 20 °C

3: dichloromethane / 16 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

5: Diacel AD prep column / methanol / Resolution of racemate

With water; lithium hydroxide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1289570-80-4
[1-(3-chloro-2-fluorophenyl)meth-(E)-ylidene]methylamine

: 1289570-77-9
4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

: 1289570-78-0
4-({[(2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl]amino}methyl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C

2: dichloromethane / 16 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: Diacel AD prep column / methanol / Resolution of racemate

With water; lithium hydroxide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1289570-77-9
4-({[(2S,3S,4S)-2-(3-Chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-methyl)-2-fluoro-benzoic acid

: 1289570-78-0
4-({[(2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl]amino}methyl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / Reflux

2: hydrogen / Raney Nickel / methanol / 18 h / 2585.81 Torr

3: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: dichloromethane / 16 h / 20 °C

5: water; lithium hydroxide / tetrahydrofuran / 20 °C

6: Diacel AD prep column / methanol / Resolution of racemate

With water; hydrogen; toluene-4-sulfonic acid; lithium hydroxide; Raney Nickel; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;