Technology Process of ONO-7475
There total 6 articles about ONO-7475 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 21h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium tert-butylate / N,N-dimethyl-formamide / 21 h / 20 °C
2: ethanol / 6 h / 20 °C
3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 21 h / 20 °C
With
potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU;
In
ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / chlorobenzene / 120 h / 140 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 16.5 h / 80 °C / Inert atmosphere
2.2: 2 h / 80 °C
3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 21 h / 20 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide; chlorobenzene;