(1-Ethylpiperidin-4-YL)methanol

Base Information

• Chemical Name: (1-Ethylpiperidin-4-YL)methanol
• CAS No.: 90226-87-2
• Molecular Formula: C8H17NO
• Molecular Weight: 143.2267
• Hs Code.: 2933399090
• European Community (EC) Number: 960-728-8
• DSSTox Substance ID: DTXSID50573517
• Wikidata: Q82462255
• Mol file: 90226-87-2.mol

Synonyms:(1-ETHYLPIPERIDIN-4-YL)METHANOL;90226-87-2;(1-Ethyl-piperidin-4-yl)-methanol;(1-ethyl-4-piperidinyl)methanol;SCHEMBL1839093;DTXSID50573517;FLOQYJOORROJQU-UHFFFAOYSA-N;MFCD08059823;AKOS005290757;SB39739;AC-25675;DS-13632;AM20120302;CS-0145214;(1-Ethylpiperidin-4-yl)methanol, AldrichCPR;A860871;J-500172

Chemical Property of (1-Ethylpiperidin-4-YL)methanol

Chemical Property:

• Vapor Pressure: 0.045mmHg at 25°C
• Refractive Index: 1.4790 (589.3 nm 20℃)
• Boiling Point: 209.99 ºC at 760 mmHg
• PKA: 14.94±0.10(Predicted)
• Flash Point: 80.217 ºC
• PSA: 23.47000
• Density: 0.932 g/cm³
• LogP: 0.64850
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

97% ^*data from raw suppliers

(1-Ethylpiperidin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCC(CC1)CO

Technology Process of (1-Ethylpiperidin-4-YL)methanol

There total 2 articles about (1-Ethylpiperidin-4-YL)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetyl-piperidine-4-carboxylic acid methyl ester (126291-66-5) → 1-ethyl-4-hydroxymethylpiperidine (90226-87-2)

Guidance literature:

1-acetyl-piperidine-4-carboxylic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

→ 1-ethyl-4-hydroxymethylpiperidine (90226-87-2)

Guidance literature:

aus 1-Acetyl-piperidin-4-carbonsaeureaethylester, LiAlH4;

Reference yield:

1-ethyl-4-hydroxymethylpiperidine (90226-87-2) + 5-Fluoro-2-nitrotoluene (446-33-3) → 1-ethyl-4-[(3-methyl-4-nitrophenoxy)methyl]piperidine (1246532-44-4)

Guidance literature:

1-ethyl-4-hydroxymethylpiperidine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

5-Fluoro-2-nitrotoluene; In N,N-dimethyl-formamide;

upstream raw materials:

1-acetyl-piperidine-4-carboxylic acid methyl ester

Downstream raw materials:

1-ethyl-4-[(3-methyl-4-nitrophenoxy)methyl]piperidine