126291-66-5

Usage

Derivation

Derived from piperidine

Functional Groups

Carboxylic acid and methyl ester

Usage

Building block in organic synthesis and pharmaceutical research

Applications

Development of drugs and therapeutic agents

Importance

Important intermediate in the production of pharmaceuticals and other organic compounds

Synthesis

Used in the synthesis of complex molecules and materials for research purposes

Upstream product

• 2971-79-1 isonipecotic acid methyl ester 
• 108-24-7 acetic anhydride 
• 25503-90-6 1-acetyl-piperidine-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 95037-48-2 1-acetyl-piperidine-4-carbonyl chloride hydrochloride 

Downstream Products

• 69835-75-2 1-acetyl-piperidine-4-carboxylic acid hydrazide 
• 90226-87-2 1-ethyl-4-hydroxymethylpiperidine 

Relevant academic research and scientific papers

FUSED TRIAZOLE TACHYKININ RECEPTOR ANTAGONISTS

The present invention is directed to certain fused triazole compounds which are useful as neurokinin-1 (NK-I) receptor antagonists, and inhibitors of tachykinin and in particular substance P- The invention is also concerned with pharmaceutical formulation

COMPOUND LIBRARIES OF N-(AMINOCARBONYL)-PIPERIDINE-4-CARBOXAMIDE DERIVATIVES CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS

The present invention provides a compound library targeted to receptors with a requirement for a positively charged amine in their structure activity relationships. It is designed to produce both agonists and antagonists and so is expected to be especially useful in producing ligands for orphan receptors. The library is designed around an acylurea coupled to a piperidine moiety. A combination of specific motifs R2 and R1 are appended from the central scaffold and are designed to pick up different interactions at a receptor site. The library comprises or consists of a set of structurally related compounds of general formula (I).