H₂N-Arg(Pbf)-Gly-OBn

Base Information

• Chemical Name: H₂N-Arg(Pbf)-Gly-OBn
• CAS No.: 1273327-72-2
• Molecular Formula: C₂₈H₃₉N₅O₆S
• Molecular Weight: 573.714
• Mol file: 1273327-72-2.mol

Synonyms:

Chemical Property of H₂N-Arg(Pbf)-Gly-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H₂N-Arg(Pbf)-Gly-OBn

There total 3 articles about H₂N-Arg(Pbf)-Gly-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H47N5O8S → H2N-Arg(Pbf)-Gly-OBn (1273327-72-2)

Guidance literature:

With formic acid; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1002/cbic.201600642

Reference yield:

benzyl 2-aminoacetate hydrochloride (2462-31-9) → H2N-Arg(Pbf)-Gly-OBn (1273327-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: formic acid / 5 h / 20 °C / Inert atmosphere

With formic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1002/cbic.201600642

Reference yield:

(S)-2-(tert-butoxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid (186698-61-3) → H2N-Arg(Pbf)-Gly-OBn (1273327-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: formic acid / 5 h / 20 °C / Inert atmosphere

With formic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1002/cbic.201600642

upstream raw materials:

(S)-2-(tert-butoxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid

benzyl 2-aminoacetate hydrochloride

Downstream raw materials:

C₂₆H₃₆N₈O₇

C₄₃H₆₀N₈O₁₀S

C₅₈H₇₄N₈O₁₃S

C₅₀H₆₆N₈O₁₃S