Boc-NH-PEG(5)-COOH(22atoms)

Base Information

Chemical Name:Boc-NH-PEG(5)-COOH(22atoms)
CAS No.:391684-36-9
Molecular Formula:C19H37NO10
Molecular Weight:439.503
Hs Code.:
Mol file:391684-36-9.mol

Synonyms:20-([(tert-butoxy)carbonyl]amino)-3,6,9,12,15,18-hexaoxaicosanoic acid;

Suppliers and Price of Boc-NH-PEG(5)-COOH(22atoms)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
BocNH-PEG6-acid
1 g
$ 624.00

Sigma-Aldrich
BocNH-PEG6-acid
250 mg
$ 203.00

BroadPharm
t-Boc-N-amido-PEG6-CH2CO2H 98%
250 MG
$ 240.00

BroadPharm
t-Boc-N-amido-PEG6-CH2CO2H 98%
500 MG
$ 380.00

BroadPharm
t-Boc-N-amido-PEG6-CH2CO2H 98%
1 G
$ 540.00

Acrotein
BocNH-PEG6-CH2COOH 97%
1g
$ 458.33

Acrotein
BocNH-PEG6-CH2COOH 97%
0.5g
$ 302.50

Total 14 raw suppliers

Chemical Property of Boc-NH-PEG(5)-COOH(22atoms)

Chemical Property:

PSA：131.01000
LogP:1.08620
Storage Temp.:-20°C

Purity/Quality:

99.3% ^*data from raw suppliers

BocNH-PEG6-acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description t-Boc-N-amido-PEG6-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Technology Process of Boc-NH-PEG(5)-COOH(22atoms)

There total 7 articles about Boc-NH-PEG(5)-COOH(22atoms) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1197192-17-8
ethyl 2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetate

: 391684-36-9
2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid

Guidance literature:: With water; lithium hydroxide; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jm901133z

Reference yield: 42.7%

: 24424-99-5
di-tert-butyl dicarbonate

: 20-(1,3-dioxoisoindolin-2-yl)-3,6,9,12,15,18-hexaoxaicosan-1-oic acid

: 391684-36-9
2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid

Guidance literature:: 20-(1,3-dioxoisoindolin-2-yl)-3,6,9,12,15,18-hexaoxaicosan-1-oic acid; In ethanol; at 20 ℃; for 3h; Reflux;

di-tert-butyl dicarbonate; In acetonitrile; at 20 ℃; for 2h;