(1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide

Base Information

Chemical Name:(1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide
CAS No.:1616505-55-5
Molecular Formula:C₇H₁₃NO₂
Molecular Weight:143.186
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide

Chemical Property:

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Technology Process of (1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide

There total 2 articles about (1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 10487-86-2
(1R,2R)-2-methylcyclopropanecarboxylic acid

: 1616505-55-5,255864-56-3
(1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide

Guidance literature:: (1R,2R)-2-methylcyclopropanecarboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 - 25 ℃; for 2h;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 25 ℃; for 16h;

Reference yield:

: 1050392-11-4
(1R,2R)-ethyl 2-methylcyclopropanecarboxylate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1616505-55-5,255864-56-3
(1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; With trimethylaluminum; In toluene; at 0 - 20 ℃; for 1h;

(1R,2R)-ethyl 2-methylcyclopropanecarboxylate; In toluene; at 0 ℃; for 6h;
DOI:10.1016/j.tetlet.2017.05.033

Reference yield:

: 1616505-55-5,255864-56-3
(1R,2R)-N-methoxy-N,2-dimethylcyclopropanecarboxamide

: 1616505-66-8
N-{(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-[(1R,2R)-2-methylcyclopropyl]-4,4a,5,6,8,8a-hexahydropyrano[3,4-c][1,3]thiazin-2-yl}benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran; diethyl ether / 3 h / -70 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -70 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h

3.2: 2 h / 140 °C

4.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C

5.1: sodium acetate; hydroxylamine hydrochloride / ethanol; water / 16 h / 60 °C

6.1: sodium hypochlorite; triethylamine / water; dichloromethane / 0.5 h / 20 °C

7.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 °C

7.2: 1.5 h / -78 °C

8.1: acetic acid; zinc / 16 h / 20 °C

9.1: dichloromethane / 72 h / 0 - 20 °C

10.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 20 °C

With hydrogenchloride; sodium hypochlorite; lithium aluminium tetrahydride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium acetate; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;