(S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide

Base Information

• Chemical Name: (S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide
• CAS No.: 1564251-49-5
• Molecular Formula: C₄₀H₅₈BN₃O₇
• Molecular Weight: 703.727

Synonyms:

Chemical Property of (S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide

There total 10 articles about (S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-3-benzyloxymethylbutyraldehyde (99776-34-8) → (S)-2-acetamido-N5-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N1-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide (1564251-49-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tetrahydrofuran; tert-butyl alcohol / 0.67 h

2: diphenyl phosphoryl azide; triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: 34 h / Reflux

4: trifluoroacetic acid / dichloromethane / 10 h

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Cooling

With sodium chlorite; 1-hydroxy-7-aza-benzotriazole; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jm500045x

Reference yield:

(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate (1564251-62-2) → (S)-2-acetamido-N5-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N1-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide (1564251-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / tetrahydrofuran / 3 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Cooling

With 1-hydroxy-7-aza-benzotriazole; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm500045x

Reference yield:

(((2-(2,2-dimethoxyethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene (99776-33-7) → (S)-2-acetamido-N5-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N1-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide (1564251-49-5)

Guidance literature:

Multi-step reaction with 6 steps

1: acetic acid / water; tetrahydrofuran / 18 h

2: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tetrahydrofuran; tert-butyl alcohol / 0.67 h

3: diphenyl phosphoryl azide; triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: 34 h / Reflux

5: trifluoroacetic acid / dichloromethane / 10 h

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Cooling

With sodium chlorite; 1-hydroxy-7-aza-benzotriazole; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jm500045x

upstream raw materials:

(((2-(2,2-dimethoxyethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene

(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

3-(benzyloxy)-2-((benzyloxy)methyl)propan-1-amine

tert-butyl (3-(benzyloxy)-2-((benzyloxy)methyl)propyl)carbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1564251-49-5 (S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send