99776-33-7

Upstream product

• 99776-32-6 2-(hydroxymethyl)-4,4-dimethoxybutan-1-ol 
• 100-44-7 benzyl chloride 
• 24156-71-6 2-(2,2-dimethoxyethyl)malonic acid diethyl ester 

Downstream Products

• 99776-34-8 4-benzyloxy-3-benzyloxymethylbutyraldehyde 
• 33498-88-3 4-(benzyloxy)-3-((benzyloxy)methyl)butan-1-ol 
• 1556859-28-9 (((2-(2-azidoethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene 
• 1556859-32-5 5-(benzyloxy)-4-((benzyloxy)methyl)pentanenitrile 
• 1556858-78-6 C₂₇H₃₅NO₅ 
• 1564251-64-4 C₂₀H₂₇NO₂ 
• 1556858-85-5 C₂₈H₃₇NO₅ 
• 1564251-49-5 (S)-2-acetamido-N⁵-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide 
• 1564251-52-0 ((R)-1-((S)-2-acetamido-4-((3-(benzyloxy)-2-((benzyloxy)methyl)propyl)amino)-4-oxobutanamido)-3-methylbutyl)boronic acid 
• 1564251-46-2 (S)-2-acetamido-N⁴-(3-(benzyloxy)-2-((benzyloxy)methyl)propyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)succinamide 
• 366803-66-9 4-benzyloxy-3-benzyloxymethylbutanoic acid 
• 1564251-63-3 3-(benzyloxy)-2-((benzyloxy)methyl)propan-1-amine 
• 1564251-67-7 tert-butyl (3-(benzyloxy)-2-((benzyloxy)methyl)propyl)carbamate 
• 132600-88-5 ((E)-6-Benzyloxy-5-benzyloxymethyl-2-cyano-hex-1-enyl)-cyanomethyl-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Rational hopping of a peptidic scaffold into non-peptidic scaffolds: Structurally novel potent proteasome inhibitors derived from a natural product, belactosin A

Rational scaffold hopping of a natural product belactosin A derivative was successfully achieved based on the pharmacophore model constructed. The peptidic scaffold was replaced by significantly simplified non-peptidic scaffolds, by which weak belactosin A (IC50 = 1440 nM) was converted into highly potent non-peptidic inhibitors (IC50 = 26-393 nM).

GUANINE DERIVATIVE

Antivirally active compounds of the formula STR1 wherein A is STR2 wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R a ' is (CH 2) p OH, NHCONH 2 or COR a ", R a " is hydrogen, hydroxy or amino, p is 1 to 4, R b ' and R b " are independently selected from hydrogen or (CH 2) p OH, with the proviso that at least one of R b ' or R b " is hydrogen; or R b ' and R b " together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; pharmaceutical preparations containing the compounds and methods for treatment of virus infections.