ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE 0.5 HYDRATE

Base Information

• Chemical Name: ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE 0.5 HYDRATE
• CAS No.: 623564-18-1
• Molecular Formula: C₉H₁₃N₃O₂*ClH
• Molecular Weight: 231.682
• Mol file: 623564-18-1.mol

Synonyms:

Chemical Property of ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE 0.5 HYDRATE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE 0.5 HYDRATE

There total 4 articles about ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE 0.5 HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride (623564-18-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 15h; under 2068.59 Torr;

DOI:10.1021/jm060021p

Reference yield:

HCl-EtOH + ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride (623564-18-1)

Guidance literature:

Pd-C; In ethanol;

Reference yield:

ethyl Bromopyruvate (70-23-5) → 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride (623564-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dimethoxy-ethane / 2.5 h / 20 °C

1.2: 22 percent / ethanol / 2 h / Heating

2.1: 63 percent / H₂; HCl / Pd/C / ethanol / 15 h / 20 °C / 2068.59 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol;

DOI:10.1021/jm060021p

upstream raw materials:

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

ethyl Bromopyruvate

imidazo <1,2-a>pyrazine-2-carboxylic acid

Downstream raw materials:

7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester

7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carbaldehyde