3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride

Base Information

• Chemical Name: 3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride
• CAS No.: 2631-61-0
• Molecular Formula: C15H17 N O . Cl H
• Molecular Weight: 263.767
• ChEMBL ID: CHEMBL541346
• DSSTox Substance ID: DTXSID60492684
• NSC Number: 130889,12246
• Mol file: 2631-61-0.mol

Synonyms:2631-61-0;3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride;3-(dimethylamino)-1-naphthalen-2-ylpropan-1-one;hydrochloride;1-Propanone,3-(diMethylaMino)-1-(2-naphthalenyl)-, hydrochloride;CHEMBL541346;SCHEMBL4922813;DTXSID60492684;NSC12246;MFCD01571049;NSC-12246;NSC130889;AKOS027441642;JS-2998;NSC-130889;SB81543;E85089;3-(dimethylamino)-1-(2-naphthyl)-1-propanone hydrochloride;3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-onehydrochloride;3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one--hydrogen chloride (1/1)

Chemical Property of 3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride

Chemical Property:

• Vapor Pressure: 1.25E-05mmHg at 25°C
• Boiling Point: 368.7°Cat760mmHg
• Flash Point: 139.4°C
• Density: 1.072g/cm³
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 263.1076919
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCC(=O)C1=CC2=CC=CC=C2C=C1.Cl

Technology Process of 3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride

There total 3 articles about 3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N,N-dimethyl(methylene)ammonium chloride (30354-18-8) + methyl 2-naphthyl ketone (93-08-3) → 3-dimethylamino-1-(naphthalen-2-yl)propan-1-one hydrochloride (2631-61-0)

Guidance literature:

In acetonitrile; at 110 ℃; Inert atmosphere;

DOI:10.1039/c5md00131e

Reference yield: 63.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) + methyl 2-naphthyl ketone (93-08-3) → 3-dimethylamino-1-(naphthalen-2-yl)propan-1-one hydrochloride (2631-61-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 18h; Reflux;

DOI:10.1002/ejic.201700792

Reference yield:

N,N-dimethylammonium chloride (506-59-2) + methyl 2-naphthyl ketone (93-08-3) → 3-dimethylamino-1-(naphthalen-2-yl)propan-1-one hydrochloride (2631-61-0)

Guidance literature:

With hydrogenchloride; paraformaldehyde; In ethanol;

upstream raw materials:

formaldehyd

N,N-dimethylammonium chloride

methyl 2-naphthyl ketone

N,N-dimethyl(methylene)ammonium chloride

Downstream raw materials:

1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

C₂₀H₁₉NO₂

1-<2-(2-naphthoyl)ethyl>imidazole hydrochloride

2-Chloro-6-(β-naphthyl)-3-(p-tolyl)-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxide