Tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate
• CAS No.: 1188264-16-5
• Molecular Formula: C13H21 N3 O2
• Molecular Weight: 251.32500
• Mol file: 1188264-16-5.mol

Synonyms:

Chemical Property of Tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate

Chemical Property:

• PSA: 58.22000
• LogP: 2.46210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

TERT-BUTYL 3-(1H-PYRAZOL-3-YL)PIPERIDINE-1-CARBOXYLATE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate

There total 3 articles about Tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-acetylpiperidine-1-carboxylate (858643-92-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate (1188264-16-5)

Guidance literature:

tert-butyl 3-acetylpiperidine-1-carboxylate; N,N-dimethyl-formamide dimethyl acetal; In toluene; Reflux;

With hydrazine hydrate; for 3h; Reflux;

Reference yield:

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate (1188264-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; HATU / dichloromethane

2.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

3.1: toluene / Reflux

3.2: 3 h / Reflux

With triethylamine; HATU; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

Reference yield:

(±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (189442-78-2) → tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate (1188264-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

2.1: toluene / Reflux

2.2: 3 h / Reflux

In tetrahydrofuran; diethyl ether; toluene;

upstream raw materials:

tert-butyl 3-acetylpiperidine-1-carboxylate

N,N-dimethyl-formamide dimethyl acetal

N-(tert-butyloxycarbonyl)nipecotic acid

(±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

Downstream raw materials:

tert-butyl 3-(1-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate

5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole

Refernces