Technology Process of ethyl (2Z,4E)-6-((aS)-4-methylcyclohexylidene)-2,4-hexadienoate
There total 4 articles about ethyl (2Z,4E)-6-((aS)-4-methylcyclohexylidene)-2,4-hexadienoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) sodium hydride / 1.) DME, 30 min, 2.) DME, RT, 1 h
2: 89 percent / LIAlH4 / diethyl ether / 3 h / 0 °C
3: 92 percent / manganese dioxide / pentane / 2 h
4: 1.) lithium diisopropylamide (LDA) / 1.) hexane, THF, -75 deg C, 30 min, 2.) THF, hexane, from -75 deg C to RT, 2 h
With
manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; lithium diisopropyl amide;
In
diethyl ether; pentane;
DOI:10.1021/jo00365a002
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 92 percent / manganese dioxide / pentane / 2 h
2: 1.) lithium diisopropylamide (LDA) / 1.) hexane, THF, -75 deg C, 30 min, 2.) THF, hexane, from -75 deg C to RT, 2 h
With
manganese(IV) oxide; lithium diisopropyl amide;
In
pentane;
DOI:10.1021/jo00365a002
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 89 percent / LIAlH4 / diethyl ether / 3 h / 0 °C
2: 92 percent / manganese dioxide / pentane / 2 h
3: 1.) lithium diisopropylamide (LDA) / 1.) hexane, THF, -75 deg C, 30 min, 2.) THF, hexane, from -75 deg C to RT, 2 h
With
manganese(IV) oxide; lithium aluminium tetrahydride; lithium diisopropyl amide;
In
diethyl ether; pentane;
DOI:10.1021/jo00365a002
