2-(Methylamino)-1-(4-methylphenyl)-1-propanone hydrochloride

Base Information

• Chemical Name: 2-(Methylamino)-1-(4-methylphenyl)-1-propanone hydrochloride
• CAS No.: 1189726-22-4
• Molecular Formula: C₁₁H₁₅NO*ClH
• Molecular Weight: 213.707
• Hs Code.: 2922399090
• Mol file: 1189726-22-4.mol

Synonyms:1-Propanone,2-(methylamino)-1-(4-methylphenyl)-, hydrochloride (1:1);Mephedrone Hcl;Mephedrone (2-methylamino-1-p-tolylpropan-1-one);

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Chemical Property of 2-(Methylamino)-1-(4-methylphenyl)-1-propanone hydrochloride

Chemical Property:

• Melting Point: 239-241 C (dec.)
• Flash Point: 9℃
• PSA: 29.10000
• LogP: 2.86600
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO: >20mg/mL

Purity/Quality:

Safty Information:

• Pictogram(s): T,F
• Hazard Codes: T,F
• Statements: 25-43-39/23/24/25-23/24/25-11
• Safety Statements: 36/37-45-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: It is a stimulant drug related to cathinone and methcathinone. The effects of Mephedrone are reportedly comparable to those of similar drugs such as MDMA and methylone.

Technology Process of 2-(Methylamino)-1-(4-methylphenyl)-1-propanone hydrochloride

There total 7 articles about 2-(Methylamino)-1-(4-methylphenyl)-1-propanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl methyl(1-oxo-1-(p-tolyl)propan-2-yl)carbamate → (S)-4-methylmethcathinone hydrochloride (1189726-22-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 3h;

DOI:10.1111/bph.12951

Reference yield: 50.0%

2-bromo-4'-methylpropiophenone (92821-88-0,1451-82-7) + methylamine (74-89-5) → (RS)-2-methylamino-1-(4-methylphenyl)propan-1-one hydrochloride (1189726-22-4)

Guidance literature:

2-bromo-4'-methylpropiophenone; methylamine; In methanol; dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In diethyl ether; isopropyl alcohol; for 1h;

DOI:10.1111/bph.12951

Reference yield: 16.0%

α-chloro-4-methyl propiophenone (69673-92-3) + methylamine (74-89-5) → (RS)-2-methylamino-1-(4-methylphenyl)propan-1-one hydrochloride (1189726-22-4)

Guidance literature:

In tetrahydrofuran; ethanol; at 20 ℃; for 48h;

DOI:10.1111/bph.13547

upstream raw materials:

2-bromo-4'-methylpropiophenone

methylamine

4'-methylpropiophenone

α-chloro-4-methyl propiophenone

Refernces

• 1、 Benturquia, Nadia,Chevillard, Lucie,Poiré, Christophe,Roussel, Olivier,Cohier, Camille,Declèves, Xavier,Laplanche, Jean-Louis,Etheve-Quelquejeu, Mélanie,Chen, Huixiong,Mégarbane, Bruno. "Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships". . p. 891 - 901. Retrieved 2019.