Mephedrone

Base Information

• Chemical Name: Mephedrone
• CAS No.: 1189805-46-6
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• European Community (EC) Number: 663-408-3
• UNII: 8BA8T27317
• DSSTox Substance ID: DTXSID20891437
• Nikkaji Number: J2.756.280I
• Wikipedia: Mephedrone
• Wikidata: Q262613
• Pharos Ligand ID: R5NGZB4G63PC
• Metabolomics Workbench ID: 49630
• ChEMBL ID: CHEMBL4094396
• Mol file: 1189805-46-6.mol

Synonyms:4-methylmethcathinone;4-MMC compound;beta-keto-4-methylmethamphetamine;bk-4-methylmethamphetamine;mephedrone;MMCAT compound

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Mephedrone

Chemical Property:

• Melting Point: 232℃
• Boiling Point: 280.2 °C at 760 mmHg
• PKA: 7.41±0.10(Predicted)
• Flash Point: 109.6 °C
• PSA: 29.10000
• Density: 0.987 g/cm³
• LogP: 2.17650
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 171

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)C(C)NC
• Recent ClinicalTrials: Mephedrone and Alcohol Interactions in Humans
• Description: Mephedrone hydrochloride salt is a white powder, whereas its free base is a yellowish liquid at ambient temperature. Mephedrone is typically sold as water-soluble crystalline stable hydrochloride salt powder, white or lightly colored; most probably as a racemic mixture of the R and S enantiomers. The powder can be dissolved for oral/rectal use or for injection. Mephedrone has also been found as capsules containing powder and as tablets pressed from powder.
• Uses: Mephedrone is used in recreational settings because of its stimulant effects similar to amphetamines (particularlyMDMA) and cocaine. Mephedrone has no established or acknowledged medical value or use (human or veterinary). There are no indications that it may be used for any other purpose.

Technology Process of Mephedrone

There total 6 articles about Mephedrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-2-methylamino-1-(4-methylphenyl)propan-1-one hydrochloride (1189726-22-4) → 1-(4-methylphenyl)-2-methylaminopropan-1-one (1189805-46-6)

Guidance literature:

With potassium carbonate; In water; at 20 ℃;

DOI:10.1016/j.molstruc.2011.06.030

Reference yield:

1-(4-methylphenyl)-2-methylaminopropan-1-one (1189805-46-6) → 4-methylmethcathinone (1388142-32-2,1189805-46-6) + R-mephedrone (1388142-31-1,1189805-46-6)

Guidance literature:

With column LiChrospher 100 RP-18e; sulfated β-cyclodextrin; In methanol; water; at 20 ℃; Reagent/catalyst;

DOI:10.1002/chir.22341

Reference yield:

1-(4-methylphenyl)-2-methylaminopropan-1-one (1189805-46-6) → 4-methylmethcathinone (1388142-32-2,1189805-46-6) + R-mephedrone (1388142-31-1,1189805-46-6)

Guidance literature:

With column LiChrospher 100 RP-18e; sulfated β-cyclodextrin; In methanol; water; at 20 ℃; Reagent/catalyst;

DOI:10.1002/chir.22341

upstream raw materials:

2-bromo-4'-methylpropiophenone

methylamine

4'-methylpropiophenone

(RS)-2-methylamino-1-(4-methylphenyl)propan-1-one hydrochloride

Downstream raw materials:

4-methylmethcathinone

R-mephedrone

2-(methylamino)-1-(p-tolyl)propan-1-ol

Refernces

• 1、 Kadkhodaei, Kian,Kadisch, Marlene,Schmid, Martin G.. "Successful use of a novel lux i-Amylose-1 chiral column for enantioseparation of “legal highs” by HPLC". . p. 42 - 52. Retrieved 2019/11/14.
• 2、 Taschwer, Magdalena,Seidl, Yvonne,Mohr, Stefan,Schmid, Martin G.. "Chiral separation of cathinone and amphetamine derivatives by HPLC/UV using sulfated β-cyclodextrin as chiral mobile phase additive". . p. 411 - 418. Retrieved 2014/08/05.