({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

Base Information

• Chemical Name: ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester
• CAS No.: 203643-20-3
• Molecular Formula: C₃₆H₃₇N₄O₇P
• Molecular Weight: 668.686
• Mol file: 203643-20-3.mol

Synonyms:

Chemical Property of ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

There total 5 articles about ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid diphenyl ester (203643-39-4) → ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester (203643-20-3)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.25h;

DOI:10.1016/S0960-894X(98)00088-2

Reference yield:

diphenyl hydrogen phosphite (4712-55-4) → ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester (203643-20-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) EtOAc, 15 min, 2.) toluene, 65 deg C, 30 min

2: DCC / dimethylformamide / 2 h

3: 50percent TFA / CH₂Cl₂ / 0.5 h

4: pyridine / CH₂Cl₂ / 4 h

5: DBU, H₂O / acetonitrile / 0.25 h

With pyridine; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(98)00088-2

Reference yield:

[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester (206435-23-6) → ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester (203643-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1: DCC / dimethylformamide / 2 h

2: 50percent TFA / CH₂Cl₂ / 0.5 h

3: pyridine / CH₂Cl₂ / 4 h

4: DBU, H₂O / acetonitrile / 0.25 h

With pyridine; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(98)00088-2

upstream raw materials:

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid diphenyl ester

diphenyl hydrogen phosphite

[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester

({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid diphenyl ester

Downstream raw materials:

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester