({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

Base Information

• Chemical Name: ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester
• CAS No.: 206435-25-8
• Molecular Formula: C₄₂H₄₂N₅O₈P
• Molecular Weight: 775.798
• Mol file: 206435-25-8.mol

Synonyms:

Chemical Property of ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

There total 6 articles about ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyl hydrogen phosphite (4712-55-4) → ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester (206435-25-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) EtOAc, 15 min, 2.) toluene, 65 deg C, 30 min

2: DCC / dimethylformamide / 2 h

3: 50percent TFA / CH₂Cl₂ / 0.5 h

4: pyridine / CH₂Cl₂ / 4 h

5: DBU, H₂O / acetonitrile / 0.25 h

6: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine, pyridine / acetonitrile / 0.5 h

With pyridine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(98)00088-2

Reference yield:

[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester (206435-23-6) → ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester (206435-25-8)

Guidance literature:

Multi-step reaction with 5 steps

1: DCC / dimethylformamide / 2 h

2: 50percent TFA / CH₂Cl₂ / 0.5 h

3: pyridine / CH₂Cl₂ / 4 h

4: DBU, H₂O / acetonitrile / 0.25 h

5: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine, pyridine / acetonitrile / 0.5 h

With pyridine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(98)00088-2

Reference yield:

({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid diphenyl ester (227798-11-0) → ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester (206435-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 4 h

2: DBU, H₂O / acetonitrile / 0.25 h

3: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine, pyridine / acetonitrile / 0.5 h

With pyridine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;

DOI:10.1016/S0960-894X(98)00088-2

upstream raw materials:

2-(hydroxymethyl)pyridine 1-oxide

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

diphenyl hydrogen phosphite

[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester