tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

Base Information

• Chemical Name: tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate
• CAS No.: 923009-50-1
• Molecular Formula: C₁₃H₂₂N₂O₃
• Molecular Weight: 254.329
• Hs Code.: 2933990090
• Mol file: 923009-50-1.mol

Synonyms:TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE;2,7-Diazaspiro[4.5]decane-7-carboxylic acid, 1-oxo-, 1,1-diMethylethyl ester;1-Oxo-2,7-diazaspiro[4.5]decane-7-carboxylic acid tert-butyl ester;tert-Butyl 4-oxo-3,9-diazaspiro[4.5]decane-9-carboxylate

Chemical Property of tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

Chemical Property:

• Vapor Pressure: 3.8E-07mmHg at 25°C
• Boiling Point: 425℃
• PKA: 15.97±0.20(Predicted)
• Flash Point: 211℃
• PSA: 58.64000
• Density: 1.15
• LogP: 1.79030
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-oxo-3,9-diazaspiro[4.5]decane-9-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

There total 2 articles about tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 2,7-diazaspiro[4.5]decan-1-one hydrochloride (1187173-43-8) → tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (923009-50-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) → tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (923009-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2: ammonia; hydrogen / methanol; water / 3750.38 Torr

With ammonia; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.bmcl.2011.08.117

Reference yield: 70.0%

tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (923009-50-1) + ethyl iodide (75-03-6) → C15H26N2O3 (923009-51-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 60 ℃;

DOI:10.1016/j.bmcl.2011.08.117

upstream raw materials:

ethyl N-(t-butyloxycarbonyl)nipecotate

di-tert-butyl dicarbonate

2,7-diazaspiro[4.5]decan-1-one hydrochloride

Downstream raw materials:

C₁₅H₂₆N₂O₃

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