{carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

Base Information

• Chemical Name: {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid
• CAS No.: 2096496-06-7
• Molecular Formula: 4C₇H₈O₃S*3C₁₀H₁₂N₂O₆
• Molecular Weight: 1457.46
• Mol file: 2096496-06-7.mol

Synonyms:

Chemical Property of {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

There total 8 articles about {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

toluene-4-sulfonic acid (104-15-4) + {tert-butoxycarbonylmethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid tert-butyl ester (207612-91-7) → {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid (2096496-06-7,207612-93-9)

Guidance literature:

In dichloromethane; for 24h;

DOI:10.1016/S0040-4039(02)00192-2

Reference yield: 100.0%

toluene-4-sulfonic acid (104-15-4) + {tert-butoxycarbonylmethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid tert-butyl ester (207612-91-7) → {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid (2096496-06-7,207612-93-9)

Guidance literature:

In dichloromethane;

DOI:10.1016/S0960-894X(02)00194-4

Reference yield:

N-Carbobenzyloxy-N',N'-bis-(t-Butoxycarbonylmethyl)-ethylenediamine (207612-89-3) → {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid (2096496-06-7,207612-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd-C

2: CH₂Cl₂

3: TMSCl; Et₃N / acetonitrile / Heating

4: 100 percent / CH₂Cl₂

With chloro-trimethyl-silane; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; acetonitrile;

DOI:10.1016/S0960-894X(02)00194-4

upstream raw materials:

toluene-4-sulfonic acid

{tert-butoxycarbonylmethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid tert-butyl ester

[tert-Butoxycarbonylmethyl-(2-hydroxy-ethyl)-amino]-acetic acid tert-butyl ester

N-Carbobenzyloxy-N',N'-bis-(t-Butoxycarbonylmethyl)-ethylenediamine