4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile

Base Information

Chemical Name:4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile
CAS No.:277308-32-4
Molecular Formula:C₁₉H₁₄N₂S
Molecular Weight:302.4
Hs Code.:
DSSTox Substance ID:DTXSID401180449
Mol file:277308-32-4.mol

Synonyms:DTXSID401180449;277308-32-4;4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile

Suppliers and Price of 4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:302.08776963
Heavy Atom Count:22
Complexity:436

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=CSC(=N2)C(=CC3=CC=CC=C3)C#N

Technology Process of 4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile

There total 1 articles about 4-(4-Methylphenyl)-alpha-(phenylmethylene)-2-thiazoleacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 250579-91-0
4-(4-methylphenyl)-2-thiazolylacetonitrile

: 277308-32-4
3-phenyl-2-(4-p-tolyl-thiazol-2-yl)-acrylonitrile

Guidance literature:: With sodium ethanolate; In ethanol; for 1h; Ambient temperature;
DOI:10.1080/10426509808032458

Reference yield:

: 277308-32-4
3-phenyl-2-(4-p-tolyl-thiazol-2-yl)-acrylonitrile

: 4-p-tolyl-2-(2,4,5-triphenyl-2H-pyrazol-3-yl)-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / toluene / 4 h / Ambient temperature

2: MeONa / methanol / Heating

With sodium methylate; triethylamine; In methanol; toluene;
DOI:10.1080/10426509808032458