(S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

Base Information

Chemical Name:(S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate
CAS No.:946618-47-9
Molecular Formula:C₃₈H₅₀Cl₃N₃O₅Si₂
Molecular Weight:791.362
Hs Code.:

(S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

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Chemical Property of (S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

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Technology Process of (S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

There total 4 articles about (S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946618-45-7
ethyl 2-amino-3[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanote

: 362512-44-5
[2-(4-chlorophenyl)-6,8-dichloroimidazo[1,2-a]pyridin-3-yl]acetic acid

: 946618-47-9
(S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

Guidance literature:: With TEA; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1007/s11095-007-9255-y

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 946618-47-9
(S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / 3 h / 50 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; TEA; DBU / acetonitrile / 18 h / 20 °C

3: EEDQ; TEA / tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; TEA; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; acetonitrile;
DOI:10.1007/s11095-007-9255-y

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 946618-47-9
(S)-ethyl-2-{2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; TEA; DBU / acetonitrile / 18 h / 20 °C

2: EEDQ; TEA / tetrahydrofuran / 15 h / 20 °C

With TEA; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; acetonitrile;
DOI:10.1007/s11095-007-9255-y