6-Bromo-2,3-dihydrobenzofuran-5-ol

Base Information

• Chemical Name: 6-Bromo-2,3-dihydrobenzofuran-5-ol
• CAS No.: 40492-53-3
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.046
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID801296187
• Nikkaji Number: J1.572.891D
• Mol file: 40492-53-3.mol

Synonyms:6-Bromo-2,3-dihydrobenzofuran-5-ol;40492-53-3;6-BROMO-2,3-DIHYDRO-1-BENZOFURAN-5-OL;6-bromo-2,3-dihydro-5-Benzofuranol;SCHEMBL10459577;VSIXVCKSNOWMCY-UHFFFAOYSA-N;DTXSID801296187;2,3-dihydro-6-bromo-5-benzofuranol

Chemical Property of 6-Bromo-2,3-dihydrobenzofuran-5-ol

Chemical Property:

• Melting Point: 115-117 °C
• Boiling Point: 288.7±40.0 °C(Predicted)
• PKA: 9.03±0.20(Predicted)
• PSA: 29.46000
• Density: 1.731±0.06 g/cm3(Predicted)
• LogP: 2.08960
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 213.96294
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

95% ^*data from raw suppliers

6-bromo-2,3-dihydrobenzofuran-5-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=CC(=C(C=C21)O)Br

Technology Process of 6-Bromo-2,3-dihydrobenzofuran-5-ol

There total 14 articles about 6-Bromo-2,3-dihydrobenzofuran-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

2,3-dihydrobenzofuran-5-ol (40492-52-2) → 2,3-dihydro-6-bromo-5-hydroxybenzofuran (40492-53-3)

Guidance literature:

With bromine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00125a014

Reference yield: 73.0%

5-bromo-2-(2'-hydroxyethyl)-1,4-benzoquinone (359844-46-5) → 2,3-dihydro-6-bromo-5-hydroxybenzofuran (40492-53-3)

Guidance literature:

With 2-cyclohexene-1,4-dione; pyridinium p-toluenesulfonate; In toluene; for 2h; Heating;

DOI:10.1021/jo000696e

Reference yield: 30.0%

5-bromo-2-(2'-hydroxyethyl)-1,4-benzoquinone (359844-46-5) → 2,3-dihydro-6-bromo-5-hydroxybenzofuran (40492-53-3) + 3-bromo-6-(2'-hydroxy)ethyl-1,4-dihydrobenzoquinone

Guidance literature:

With 2-cyclohexene-1,4-dione; pyridinium p-toluenesulfonate; In toluene; for 6h; Heating;

DOI:10.1021/jo000696e

upstream raw materials:

2,3-dihydrobenzofuran-5-ol

2,5-dihydroxy-4-bromophenethylbromide

5-bromo-2-(2'-hydroxyethyl)-1,4-benzoquinone

3-bromo-4-methoxy-phenol

Downstream raw materials:

2,3-Dihydro-5-hydroxy-6-<3-(2-methoxycarbonylphenyl)-2-propenyl>benzofuran

6-(3-(2-hydroxymethylphenyl)-trans-prop-2-enyl)-5-hydroxy-2,3-dihydrobenzofuran

6-<3-(2-Cyanophenyl)-2-propenyl>-2,3-dihydro-5-hydroxybenzofuran

6-<3-(2-Bromophenyl)-2-propenyl>-2,3-dihydro-5-hydroxybenzofuran