13391-30-5

Upstream product

• 121767-80-4 2-bromo-1-(2-chloroethoxy)-4-methoxybenzene 

Downstream Products

• 99355-75-6 5-methoxy-2,3-dihydrobenzofuran-6-carboxaldehyde 
• 156297-76-6 7-Formyl-5-methoxy-2,3-dihydrobenzofuran 
• 102539-64-0 6-acetyl-5-hydroxybenzofuran 
• 7182-32-3 2-phenyl-5-methoxybenzo[b]furan 
• 156488-99-2 N-(5-Methoxy-2,3-dihydro-benzofuran-6-yl)-3-(2-nitro-phenyl)-3-oxo-propionamide 
• 156489-00-8 5-Methoxy-9-(2-nitro-phenyl)-3,6-dihydro-2H-furo[2,3-f]quinolin-7-one 
• 156489-03-1 4,7-Dichloro-9-(2-nitro-phenyl)-2,3-dihydro-furo[2,3-f]quinolin-5-ol 
• 156489-04-2 2,7-Dichloro-6-(2-hydroxy-ethyl)-4-(2-nitro-phenyl)-quinoline-5,8-dione 
• 156489-01-9 7-Chloro-5-methoxy-9-(2-nitro-phenyl)-2,3-dihydro-furo[2,3-f]quinoline 
• 156489-02-0 2-Chloro-6-(2-hydroxy-ethyl)-4-(2-nitro-phenyl)-quinoline-5,8-dione 
• 40492-52-2 2,3-dihydrobenzofuran-5-ol 
• 99385-68-9 N-(4-acetylphenyl)-6-(aminomethyl)-5-hydroxy-2,3-dihydrobenzofuran 
• 99385-91-8 6-{[(E)-2,4-Difluoro-phenylimino]-methyl}-2,3-dihydro-benzofuran-5-ol 
• 99385-67-8 N-(2,4-difluorophenyl)-6-(aminomethyl)-5-hydroxy-2,3-dihydrobenzofuran 

Relevant academic research and scientific papers

The Synthesis of 5-Substituted 2,3-Dihydrobenzofurans

The preparation of 2,3-dihydrobenzofurans 6 from 2-(2-bromophenoxy)ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described.A high yielding procedure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromophenols 2.The 5-hydroxy derivative 15 may be obtained from 2,3-dihydrobenzofuran (6a) by reaction with electrophilic reagents followed by oxidation.