3,5-Dichlorobenzene-1,2-diamine

Base Information

• Chemical Name: 3,5-Dichlorobenzene-1,2-diamine
• CAS No.: 5233-04-5
• Molecular Formula: C6H6Cl2N2
• Molecular Weight: 177.033
• Hs Code.: 2921590090
• European Community (EC) Number: 686-949-7
• DSSTox Substance ID: DTXSID40401476
• Nikkaji Number: J80.981K
• Wikidata: Q82204605
• Mol file: 5233-04-5.mol

Synonyms:3,5-dichlorobenzene-1,2-diamine;5233-04-5;3,5-Dichloro-1,2-diaminobenzene;(2-AMINO-3,5-DICHLOROPHENYL)AMINE;3,5-Dichloro-1,2-benzenediamine;3,5-Dichloro-1,2-phenylenediamine;CHEMBRDG-BB 5366312;MFCD00628987;SCHEMBL4705245;3,5-dichloro-o-phenylenediamine;,2-Diamino-3,5-dichlorobenzene;2-amino-3,5-dichlorophenylamine;DTXSID40401476;YWPGZWRHHRUXEK-UHFFFAOYSA-N;1,2-diamino-3,5-dichlorobenzene;AKOS005067034;3,5-Dichloro-1,2-diaminobenzene, 97%;CS-0157716;FT-0649707;EN300-120050;3 pound not5-Dichlorobenzene-1 pound not2-diamine;AE-641/33431006

Chemical Property of 3,5-Dichlorobenzene-1,2-diamine

Chemical Property:

• Vapor Pressure: 0.000372mmHg at 25°C
• Melting Point: 60-65°C
• Boiling Point: 318°C at 760 mmHg
• PKA: 2.05±0.10(Predicted)
• Flash Point: 146.1°C
• PSA: 52.04000
• Density: 1.501g/cm³
• LogP: 3.32020
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 175.9908036
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dichloro-1,2-diaminobenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1N)N)Cl)Cl

Technology Process of 3,5-Dichlorobenzene-1,2-diamine

There total 8 articles about 3,5-Dichlorobenzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,4-dichloro-6-nitroaniline (2683-43-4) → 3,5-dichloro-1,2-phenylenediamine (5233-04-5)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 24h;

Reference yield:

SnCl2 °2H2 O + 2,4-dichloro-6-nitroaniline (2683-43-4) → 3,5-dichloro-1,2-phenylenediamine (5233-04-5)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; ethyl acetate;

Reference yield:

SnCl2 + 2,4-dichloro-6-nitroaniline (2683-43-4) → 3,5-dichloro-1,2-phenylenediamine (5233-04-5)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

2,4-dichloro-6-nitroaniline

hydrogenchloride

N-(2,4-dichlorophenyl)acetamide

Acetanilid

Downstream raw materials:

4,6-dichloro-2-methyl-1H-benzimidazole

5,7-dichlorobenzo-2,1,3-thiadiazole

4,6-dichloro-1H-benzo[d]imidazole

2,4-dichloro-6-(4,6-dichloro-1H-benzimidazol-2-yl)-phenol

Refernces

• 1、 -. "As neuroprotective agents of pharmaceutical compounds". Paragraph 0642; 0643; 0646; 0647. . Retrieved 2019/06/26.
• 2、 Zou, Ruiming,Drach, John C.,Townsend, Leroy B.. "Design, synthesis, and antiviral evaluation of 2-substituted 4,5- dichloro- and 4,6-dichloro-1-β-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections". . p. 802 - 810. Retrieved 2007/10/03.