1-(tert-butoxycarbonyl)piperidine-4-carboxylid acid

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)piperidine-4-carboxylid acid
• CAS No.: 174286-31-8
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.27286
• Mol file: 174286-31-8.mol

Synonyms:1,4-Piperidinedicarboxylic acid 1-tert-butyl ester;1-(Tert-butoxycarbonyl)piperidine-4-carboxylid acid;1,4-Piperidinedicarboxylic acid 1-tert-butyl ester, labeled with deuterium

Chemical Property of 1-(tert-butoxycarbonyl)piperidine-4-carboxylid acid

Chemical Property:

• PSA: 66.84000
• LogP: 1.65600

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(tert-butoxycarbonyl)piperidine-4-carboxylid acid

There total 1 articles about 1-(tert-butoxycarbonyl)piperidine-4-carboxylid acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) + tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6)

Guidance literature:

Reference yield: 100.0%

N-(3-aminopropyl)-4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethyl-benzamide + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → tert-butyl 4-[3-[[4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethyl-benzoyl]amino]propylcarbamoyl]piperidine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 96.6%

[2-chloro-4-[[3-[4-(difluoromethoxy)-2,3-difluoro-phenyl]imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-yl-methanone 2,2,2-trifluoroacetate + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → tert-butyl 4-[4-[2-chloro-4-[[3-[4-(difluoromethoxy)-2,3-difluoro-phenyl]imidazo[1,2-a]pyrazin-8-yl]amino]benzoyl]piperazine-1-carbonyl]piperidine-1-carboxylate

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

Downstream raw materials:

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate

4-(dimethylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester

Refernces