Methyl 1-benzyl-4-hydroxypiperidine-3-carboxylate

Base Information

• Chemical Name: Methyl 1-benzyl-4-hydroxypiperidine-3-carboxylate
• CAS No.: 956010-25-6
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.337
• Hs Code.: 2933399090
• Mol file: 956010-25-6.mol

Synonyms:3-Piperidinecarboxylic acid, 4-hydroxy-1-(phenylmethyl)-, ethyl ester

Chemical Property of Methyl 1-benzyl-4-hydroxypiperidine-3-carboxylate

Chemical Property:

• PSA: 49.77000
• Density: 1.160
• LogP: 0.98030

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1-Benzyl-4-hydroxypiperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-benzyl-4-hydroxypiperidine-3-carboxylate

There total 2 articles about Methyl 1-benzyl-4-hydroxypiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → ethyl 1-benzyl-4-hydroxypiperidine-3-carboxylate (956010-25-6)

Guidance literature:

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride; With triethylamine; In methanol; at 20 ℃; for 0.166667h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; methanol; water; sodium hydrogencarbonate; more than 3 stages;

Reference yield: 77.0%

C9H14O3NC6H5 (41276-30-6) → ethyl 1-benzyl-4-hydroxypiperidine-3-carboxylate (956010-25-6)

Guidance literature:

With sodium tetrahydroborate; sodium carbonate; In isopropyl alcohol; at 20 ℃; for 3h;

DOI:10.1002/hlca.200490236

Reference yield: 68.0%

p-toluenesulfonyl chloride (98-59-9) + ethyl 1-benzyl-4-hydroxypiperidine-3-carboxylate (956010-25-6) → ethyl 5-((N-benzyl-4-methylphenyl)sulfonamido)pent-2-enoate

Guidance literature:

With calcium hydride; alizarin yellow R; In acetonitrile; at 20 ℃; for 24h; regiospecific reaction; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1039/d0gc00196a

upstream raw materials:

C₉H₁₄O₃NC₆H₅

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

Downstream raw materials:

(3RS,4RS)-1-benzyl-3-hydroxymethyl-piperidin-4-ol

Refernces

• 1、 -. "TRYCLIC NITROGEN CONTAINING COMPOUNDS AND THEIR USE AS ANTIBACTERIALS". Page/Page column 59. . Retrieved 2008/06/13.