Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester

Base Information

• Chemical Name: Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester
• CAS No.: 25123-05-1
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.364
• Mol file: 25123-05-1.mol

Synonyms:(-)-Propionic acid (3R,4R)-1,3-dimethyl-4-phenylpiperidin-4-yl ester;

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Chemical Property of Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester

Chemical Property:

• PSA: 29.54000
• LogP: 2.74460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester

There total 8 articles about Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

(-)-β-prodinol (46366-96-5) + propionic acid anhydride (123-62-6) → (-)-β-prodine (25123-05-1)

Guidance literature:

In pyridine; for 3h; Heating;

Reference yield:

1,3-dimethyl-4-piperidinone (4629-80-5) → (+/-)-β-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0) + (+/-)-α-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0)

Guidance literature:

With diethyl ether; phenyllithium;

DOI:10.1021/jo01170a024

Reference yield:

1,3-dimethyl-4-piperidinone (4629-80-5) → (+/-)-β-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0) + (+/-)-α-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0)

Guidance literature:

With diethyl ether; phenyllithium;

DOI:10.1021/jo01170a024

upstream raw materials:

1,3-dimethyl-4-piperidinone

1,3,5-trimethyl-1,3,5-triazacyclohexane

1-ethylstyrene

propionic acid anhydride

Downstream raw materials:

(+/-)-α-4-hydroxy-3-methyl-4-phenylpiperidine

α-4-hydroxy-3-methyl-4-phenyl-1-propanoylpiperidine

(+/-)-α-1-(1-cyanocyclohexyl)-4-hydroxy-3-methyl-4-phenylpiperidine

(+/-)-α-4-hydroxy-3-methyl-4-phenyl-1-(1-phenylcyclohexyl)piperidine