2-(2-Methyl-1,3-dioxolan-2-yl)ethanamine

Base Information

• Chemical Name: 2-(2-Methyl-1,3-dioxolan-2-yl)ethanamine
• CAS No.: 62240-37-3
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2932999099
• European Community (EC) Number: 804-004-0
• DSSTox Substance ID: DTXSID50449086
• Nikkaji Number: J1.526.478K
• Wikidata: Q82268423
• Mol file: 62240-37-3.mol

Synonyms:62240-37-3;2-(2-methyl-1,3-dioxolan-2-yl)ethanamine;2-Methyl-1,3-dioxolane-2-ethanamine;2-(Aminoethyl)-2-methyl-1,3-dioxolane;2-(2-methyl-1,3-dioxolan-2-yl)ethan-1-amine;2-(2-METHYL-[1,3]DIOXOLAN-2-YL)-ETHYLAMINE;MFCD09923503;1,3-Dioxolane-2-ethanamine, 2-methyl-;2-(2-Aminoethyl)-2-methyl-1,3-dioxolane;4-Amino-2-butanone ethylene acetal;SCHEMBL1557177;DTXSID50449086;GVVWCRQQBUQLMZ-UHFFFAOYSA-N;4-aminobutan-2-one ethylene acetal;AMY20115;AKOS005264836;CS-W013426;SB37972;AS-36303;SY008158;FT-0660431;EN300-77061;2-Methyl-1,3-dioxolane-2-ethanamine, AldrichCPR;A868521;J-509899

Chemical Property of 2-(2-Methyl-1,3-dioxolan-2-yl)ethanamine

Chemical Property:

• Vapor Pressure: 1.001mmHg at 25°C
• Refractive Index: 1.442
• Boiling Point: 178.2 °C at 760 mmHg
• PKA: 10.33±0.10(Predicted)
• Flash Point: 63.957 °C
• PSA: 44.48000
• Density: 1.005 g/cm³
• LogP: 0.79850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Aminoethyl)-2-methyl-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-52
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OCCO1)CCN
• Uses: 2-(Aminoethyl)-2-methyl-1,3-dioxolane can be used in the total synthesis of (+/-)-Methyl Homodaphniphyllate.

Technology Process of 2-(2-Methyl-1,3-dioxolan-2-yl)ethanamine

There total 2 articles about 2-(2-Methyl-1,3-dioxolan-2-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)isoindoline-1,3-dione (84764-41-0) → 2-(2-methyl-1,3-dioxolane-2-yl)ethan-1-amine (62240-37-3)

Guidance literature:

With hydrazine hydrate; In methanol; for 4h; Heating;

DOI:10.1021/jo00035a007

Reference yield:

→ 2-(2-methyl-1,3-dioxolane-2-yl)ethan-1-amine (62240-37-3)

Guidance literature:

With water; hydrazine hydrate;

DOI:10.1039/jr9550003151

Reference yield: 99.0%

2-(2-methyl-1,3-dioxolane-2-yl)ethan-1-amine (62240-37-3) + 1-(phenylsulfonyl)-1H-indole-2-carbaldehyde (80360-23-2) → 3,3-(ethylenedioxy)-N-<<1-(phenylsulfonyl)-2-indolyl>methylene>butylamine (130179-19-0)

Guidance literature:

In benzene; 1.) 0 deg C, 30 min 2.) room temperature 3.) 19 h reflux;

DOI:10.1016/S0040-4020(01)86779-X

upstream raw materials:

2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)isoindoline-1,3-dione

Downstream raw materials:

[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-carbamic acid methyl ester

3,3-(ethylenedioxy)-N-<<1-(phenylsulfonyl)-2-indolyl>methylene>butylamine

[1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(Z)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine

N-(3,4-dimethoxybenzilidene)-3,3-ethylenedioxybutylamine