[1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Base Information

• Chemical Name: [1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine
• CAS No.: 130627-33-7
• Molecular Formula: C₂₁H₂₂N₂O₄S
• Molecular Weight: 398.483
• Mol file: 130627-33-7.mol

Synonyms:[1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Chemical Property of [1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine

There total 1 articles about [1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methyl-1,3-dioxolane-2-yl)ethan-1-amine (62240-37-3) + 1-(phenylsulfonyl)indole-3-carbaldehyde (80360-20-9) → [1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(Z)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine (130627-33-7)

Guidance literature:

In benzene; 1) 0 deg C, 30 min, 2) 1 h, heating, 3) 16 h, heating (Dean Stark);

DOI:10.1016/S0040-4039(00)89061-9

Reference yield: 72.0%

[1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine (130627-33-7) → 2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal (140858-28-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 1h; Heating;

DOI:10.1021/jo00022a015

Reference yield:

[1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine (130627-33-7) → N-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal (130627-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / p-TsOH / benzene / 1 h / Heating

2: 62 percent / K₂CO₃ / ethanol / 15 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; benzene;

DOI:10.1021/jo00022a015

upstream raw materials:

2-(2-methyl-1,3-dioxolane-2-yl)ethan-1-amine

1-(phenylsulfonyl)indole-3-carbaldehyde

Downstream raw materials:

2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

N-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

3,4,6,7,12,12b-Hexahydro-1H-indolo[2,3-a]quinolizin-2-one