ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
• CAS No.: 131748-96-4
• Molecular Formula: C7H6F3NO2S
• Molecular Weight: 225.19
• Hs Code.: 29349990
• Mol file: 131748-96-4.mol

Synonyms:5-Thiazolecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester;Ethyl 2-(trifluoromethyl)-1,3-thiazole-5-carboxylate

Chemical Property of ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.433mmHg at 25°C
• Refractive Index: 1.463
• Boiling Point: 194.801 °C at 760 mmHg
• PKA: -2.02±0.10(Predicted)
• Flash Point: 71.613 °C
• PSA: 67.43000
• Density: 1.407 g/cm³
• LogP: 2.33860
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 2-(trifluoromethyl)thiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE

There total 1 articles about ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-chloro-3-oxopropanoate (33142-21-1) + trifluorothioacetamide (421-52-3) → ethyl 2-(trifluoromethyl)thiazole-5-carboxylate (131748-96-4)

Guidance literature:

In dichloromethane;

Reference yield: 75.0%

ethyl 2-(trifluoromethyl)thiazole-5-carboxylate (131748-96-4) → 2-(trifluoromethyl)-1,3-thiazole-5-carbaldehyde (903130-38-1)

Guidance literature:

ethyl 2-(trifluoromethyl) thiazole-5-carboxylate; With diisobutylaluminium hydride; In dichloromethane; at -70 ℃; for 1.66667h; Inert atmosphere;

With water; sodium hydroxide; In dichloromethane; at 0 ℃; for 0.0833333h;

Reference yield: 73.0%

ethyl 2-(trifluoromethyl)thiazole-5-carboxylate (131748-96-4) → (2-(trifluoromethyl) thiazol-5-yl)methanol (131748-97-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

upstream raw materials:

ethyl 2-chloro-3-oxopropanoate

trifluorothioacetamide

Downstream raw materials:

2-(trifluoromethyl)-1,3-thiazole-5-carbaldehyde

(2-(trifluoromethyl) thiazol-5-yl)methanol

(2-(trifluoromethyl) thiazol-5-yl)methanamine

Refernces