2-Amino-5-chloropyridin-3-ol

Base Information

• Chemical Name: 2-Amino-5-chloropyridin-3-ol
• CAS No.: 40966-87-8
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.56
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID30437961
• Wikidata: Q72437735
• Mol file: 40966-87-8.mol

Synonyms:2-Amino-5-chloropyridin-3-ol;40966-87-8;2-Amino-3-hydroxy-5-chloropyridine;2-amino-5-chloro-3-hydroxypyridine;3-Pyridinol, 2-amino-5-chloro-;MFCD14706179;2-amino-5-chloro-3-pyridinol;SCHEMBL131341;DTXSID30437961;BMRXXBXPVJOAMM-UHFFFAOYSA-N;2-azanyl-5-chloranyl-pyridin-3-ol;BBL102418;STL556220;AKOS006339202;CS-W003868;AC-29190;AS-18354;SY028332;FT-0660262;EN300-113168;2-Amino-5-chloro-3-hydroxypyridine, AldrichCPR;A825368

Chemical Property of 2-Amino-5-chloropyridin-3-ol

Chemical Property:

• Vapor Pressure: 1.95E-06mmHg at 25°C
• Melting Point: 198-201 °C
• Refractive Index: 1.664
• Boiling Point: 383.7 °C at 760 mmHg
• PKA: 11.48±0.10(Predicted)
• Flash Point: 185.9 °C
• PSA: 59.14000
• Density: 1.516 g/cm³
• LogP: 1.60400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 144.0090405
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-chloropyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1O)N)Cl

Technology Process of 2-Amino-5-chloropyridin-3-ol

There total 7 articles about 2-Amino-5-chloropyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

→ 2-amino-5-chloro-3-hydroxypyridine (40966-87-8)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 0.5h; Reflux;

Reference yield: 80.0%

6-chlorooxazole[4,5-b]pyridine-2(3H)-one (35570-68-4) → 2-amino-5-chloro-3-hydroxypyridine (40966-87-8)

Guidance literature:

With sodium hydroxide; at 130 ℃; for 16h;

Reference yield:

2-amino-3-hydroxypyridine (16867-03-1) → 2-amino-5-chloro-3-hydroxypyridine (40966-87-8)

Guidance literature:

With chlorine; In sulfuric acid;

upstream raw materials:

2-amino-3-hydroxypyridine

copper

2-amino-3-bromo-5-chloropyridine

3,5-dichloropyridin-2-amine

Downstream raw materials:

3-(Benzyloxy)-5-chloro-2-pyridinamine

2-(2-amino-5-chloro-pyridin-3-yloxy)-N-benzyl-acetamide

6-chlorooxazole[4,5-b]pyridine-2(3H)-one