35570-68-4

Basic information

• Product Name: 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
• Synonyms: 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one;6-Chloro-3H-oxazolo[4,5-b]pyridin-2-one;Oxazolo[4,5-b]pyridin-2(3H)-one, 6-chloro-;6-chloro-3H-[1,3]oxazolo[4,5-b]pyridin-2-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)
• CAS NO: 35570-68-4
• Molecular Formula: C₆H₃ClN₂O₂
• Molecular Weight: 170.55
• Mol File: 35570-68-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 183-186℃
• Appearance: /
• Density: 1.80
• Refractive Index: 1.611
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one(35570-68-4)
• EPA Substance Registry System: 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one(35570-68-4)

Safety Data

• Hazardous Substances Data: 35570-68-4(Hazardous Substances Data)

Usage

General Description

6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one is a chemical compound with the molecular formula C7H4ClNO2. It is a heterocyclic compound that contains a chlorine atom and is used in pharmaceutical research and drug development. This chemical may have potential applications in the synthesis of various biologically active compounds, due to its unique structure and properties. Additionally, it may also have potential uses in the field of agrochemicals and materials science. Further research and development of 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one may lead to the discovery of new drugs and other valuable compounds.

InChI:InChI=1/C6H3ClN2O2/c7-3-1-4-5(8-2-3)9-6(10)11-4/h1-2H,(H,8,9,10)

Upstream product

• 60832-72-6 2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one 
• 15177-57-8 3,5-dicholoropyridine N-oxide 
• 4083-64-1 Tosyl isocyanate 
• 128-09-6 N-chloro-succinimide 
• 75-44-5 phosgene 
• 40966-87-8 2-amino-5-chloro-3-hydroxypyridine 
• 16867-03-1 2-amino-3-hydroxypyridine 

Downstream Products

• 35575-92-9 ethyl-phosphonodithioic acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-methyl ester 
• 35570-70-8 6-chloro-3-chloromethyl-3H-oxazolo[4,5-b]pyridin-2-one 
• 37419-16-2 methyl-phosphonodithioic acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-methyl ester 
• 35575-81-6 methyl-phosphonodithioic acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-ethyl ester 
• 37429-95-1 ethyl-phosphonodithioic acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-ethyl ester 
• 35575-96-3 S-((6-chloro-2,3-dihydro-2-oxo-1,3-oxazolo[4,5-b]pyridin-3-yl)methyl) O,O-dimethyl phosphorothioate 
• 35570-72-0 azamethiphos 
• 53131-34-3 dithiophosphoric acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-ethyl ester S'-propyl ester 
• 35570-75-3 phenyl-phosphonodithioic acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-methyl ester 
• 35575-77-0 phenyl-phosphonodithioic acid S-(6-chloro-2-oxo-oxazolo[4,5-b]pyridin-3-ylmethyl) ester O-ethyl ester 
• 40966-87-8 2-amino-5-chloro-3-hydroxypyridine 

Relevant articles and documents

-

-

HETEROARYL COMPOUNDS AS KINASE INHIBITOR

Provided herein are heteroaryl compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R 1, R 2, R 3, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.

6-chloro -3H-oxazole and [4,5-b] pyridine-2-one of the one-step synthesis method

The invention belongs to the field of organic synthesis, and particularly relates to a one-step synthesis method of 6-chlorine-3H-oxazole [4,5-b] pyridine-2-ketone. The one-step synthesis method of 6-chlorine-3H-oxazole [4,5-b] pyridine-2-ketone comprises the step as follows: oxazole [4,5-b] pyridine-2(3H)-ketone reacts with NCS(N-chlorosuccinimide) in a proper solvent at proper temperature, so as to generate 6-chlorine oxazole [4,5-b] pyridine-2(3H)-ketone. The 6-chlorine-3H-oxazole [4,5-b] pyridine-2-ketone is prepared by adopting a one-step method by reaction disclosed by the invention. The 6-chlorine-3H-oxazole [4,5-b] pyridine-2-ketone is cheap and available in raw materials, the method is simple and convenient to operate, mild in reaction condition, low in production cost, and easy in achieving industrial amplification, and the yield can be up to 89%.