4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE

Base Information

• Chemical Name: 4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE
• CAS No.: 845909-49-1
• Molecular Formula: C8H15ClFNO2
• Molecular Weight: 211.664
• Hs Code.: 2933399090
• Mol file: 845909-49-1.mol

Synonyms:Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride;

Chemical Property of 4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE

Chemical Property:

• PSA: 38.33000
• LogP: 1.77200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-fluoropiperidine-4-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 4-fluoropiperidine-4-carboxylate, HCl

Technology Process of 4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE

There total 3 articles about 4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-fluoropiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (416852-82-9) → ethyl 4-fluoropiperidine-4-carboxylate hydrochloride (845909-49-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃;

Reference yield:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → ethyl 4-fluoropiperidine-4-carboxylate hydrochloride (845909-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

1.2: -78 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Cooling with ice

With hydrogenchloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

→ ethyl 4-fluoropiperidine-4-carboxylate hydrochloride (845909-49-1)

Guidance literature:

upstream raw materials:

4-fluoropiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Downstream raw materials:

C₁₅H₁₉ClFNO₅S

ethyl 4-fluoro-1-(5-(4-(2-methoxyethoxy)benzyl)pyrimidin-2-yl)piperidine-4-carboxylate

ethyl 4-fluoro-1-(4-((4-fluorophenoxy)methyl)pyrimidin-2-yl)piperidine-4-carboxylate

4-fluoro-1-(5-(4-fluorophenoxy)pyridin-3-yl)piperidine-4-carboxylic acid

Refernces

• 1、 -. "NOVEL IMIDAZOLE COMPOUND AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONIST". Paragraph 0506. . Retrieved 2018/10/04.
• 2、 -. "ANTIBACTERIAL COMPOUNDS". Page/Page column 34; 35. . Retrieved 2012/04/18.